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Pharmacokinetic of florfenicol in pulmonary epithelial lining fluid of swine and effects of anesthetic agent on drug plasma disposition kinetics Arq. Bras. Med. Vet. Zootec.
Wang,Yanping; Zhang,Ling; Ahmed,Saeed; Liu,Yonghong; Li,Xianqiang.
ABSTRACT The primary objective of the current study was to compare the pharmacokinetic (PK) of florfenicol (FFL) in pulmonary epithelial lining fluid and the plasma in swine. The second objectives were to evaluate the effect of anesthesia with ketamine and propofol on the PK of FFL in plasma. Bronchoaveolar lavage was utilized for quantification of PELF volume and the urea dilution method was used to determine the concentration of FFL in PELF. FFL was administered intramuscularly (IM) to swine in a single dose of 20mg/kg body weight. The main PK parameters of FFL in plasma and PELF were as follows: the area under the concentration-time curve, maximal drug concentration, elimination half-life and mean residence time were 69.45±4.36 vs 85.03±9.26μg·hr/ml,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Anesthetic agent; Bronchoaveolar lavage; Florfenicol; Pharmacokinetic; Pulmonary.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352018000501497
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Development of a clinical scoring system for the diagnosis of smear-negative pulmonary tuberculosis BJID
Soto,Alonso; Solari,Lely; Agapito,Juan; Acuna-Villaorduna,Carlos; Lambert,Marie-Laurence; Gotuzzo,Eduardo; Stuyft,Patrick Van der.
This study developed a clinical score based on clinical and radiographic data for the diagnosis of smear-negative pulmonary tuberculosis (SNPT). SNPT was defined as a positive culture in Ogawa in a patient with two negative sputum smears. Data from patients admitted to the emergency ward with respiratory symptoms and negative acid-fast bacilli (AFB) smears was analyzed by means of logistic regression to develop the predictive score.Two hundred and sixty two patients were included. Twenty patients had SNPT. The variables included in the final model were hemoptysis, weight loss, age > 45 years old, productive cough, upper-lobe infiltrate, and miliary infiltrate. With those, a score was constructed. The score values ranged from -2 to 6. The area under the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Tuberculosis; Pulmonary; Regression analysis; Scoring methods.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000200006
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Rapid detection of Candida species in bronchoalveolar lavage fluid from patients with pulmonary symptoms BJM
Zarrinfar,Hossein; Kaboli,Saeed; Dolatabadi,Somayeh; Mohammadi,Rasoul.
Abstract Candida species, especially C. albicans, are commensals on human mucosal surfaces, but are increasingly becoming one of the important invasive pathogens as seen by a rise in its prevalence in immunocompromised patients and in antibiotic consumption. Thus, an accurate identification of Candida species in patients with pulmonary symptoms can provide important information for effective treatment. A total of 75 clinical isolates of Candida species were obtained from the bronchoalveolar lavage fluid of both immunocompromised and immunocompetent patients with pulmonary symptoms. Candida cultures were identified based on nuclear ribosomal Internal Transcribed Spacer (ITS1-ITS2 rDNA) sequence analysis by polymerase chain reaction–restriction fragment...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Candida; Pulmonary; PCR-RFLP.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822016000100172
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