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	Provedor de dados BJMBR (1) Autor Barreto,A.C. (1) Castro,C.R.P. (1) Franchi,S.M. (1) Lopes,A.A. (1) Palavra-chave Phosphodiesterase inhibitors (1) Pulmonary hypertension (1) Pulmonary veno-occlusive disease (1) Sildenafil (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2005 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última One-year follow-up of the effects of sildenafil on pulmonary arterial hypertension and veno-occlusive disease BJMBR Barreto,A.C.; Franchi,S.M.; Castro,C.R.P.; Lopes,A.A.. We hypothesized that chronic oral administration of the phosphodiesterase-5 inhibitor sildenafil could improve the exercise capacity and pulmonary hemodynamics in patients with pulmonary arterial hypertension (PAH) on the basis of previous short-term studies. We tested this hypothesis in 14 subjects with PAH, including seven patients with the idiopathic form and seven patients with atrial septal defects, but no other congenital heart abnormalities. Patients were subjected to a 6-min walk test and dyspnea was graded according to the Borg scale. Pulmonary flow and pressures were measured by Doppler echocardiography. Patients were given sildenafil, 75 mg orally three times a day, and followed up for 1 year. Sildenafil therapy resulted in the following... Tipo: Info:eu-repo/semantics/article Palavras-chave: Sildenafil; Pulmonary hypertension; Pulmonary veno-occlusive disease; Phosphodiesterase inhibitors. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000200006 Registros recuperados: 1 Primeira ... 1 ... Última

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