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Gastroprotective activity of the hydroethanolic extract and ethyl acetate fraction from Kalanchoe pinnata (Lam.) Pers. BJPS
Sobreira,Flávia; Hernandes,Leandro Santoro; Vetore-Neto,Alberto; Díaz,Ingrit E. Collantes; Santana,Fernanda Carvalho de; Mancini-Filho,Jorge; Bacchi,Elfriede Marianne.
ABSTRACT Peptic ulcers are an important pathology, and the search for safer and more effective treatment methods is of paramount importance. In this study, we assess the gastroprotective effects of the hydroethanolic extract (HE) and ethyl acetate fraction (EAF) from Kalanchoe pinnata leaves against an ethanol/HCl-induced ulcer model in rats. The HE reduced gastric lesions by approximately 47% (400 mg/kg). A significant inhibition of the gastric lesions by 50% was observed after pretreatment with the EAF (200 mg/kg). Quercetrin and quercetin 3-O-α-L-arabinopyranosyl-(1→2)-α-L-rhamnopyranoside were isolated and identified in the flavonoid fraction (EAF) by HPLC and NMR analyses because this fraction showed the highest gastroprotective effect. This fraction...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Gastric ulcer/study/rats; Gastric ulcer/treatment; Kalanchoe pinnata/chromatographic profile; Kalanchoe pinnata/gastroprotective activity; Quercetrin; Quercetin 3-O-α-L-arabinopyranosyl-(1→2)-α-L-rhamnopyranoside..
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000100616
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