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| Nualart,Francisco; Salazar,Katterine; Oyarce,Karina; Cisternas,Pedro; Jara,Nery; Silva-Álvarez,Carmen; Pastor,Patricia; Martínez,Fernando; García,Andrea; García-Robles,María de los Ángeles; Tapia,Juan Carlos. |
| Stem cells are considered a valuable cellular resource for tissue replacement therapies in most brain disorders. Stem cells have the ability to self-replicate and differentiate into numerous cell types, including neurons, oligodendrocytes and astrocytes. As a result, stem cells have been considered the "holy grail" of modern medical neuroscience. Despite their tremendous therapeutic potential, little is known about the mechanisms that regulate their differentiation. In this review, we analyze stem cells in embryonic and adult brains, and illustrate the differentiation pathways that give origin to most brain cells. We also evaluate the emergent role of the well known anti-oxidant, vitamin C, in stem cell differentiation. We believe that a complete... |
| Tipo: Journal article |
Palavras-chave: Stem cells; Radial glia; Vitamin C; SVCT2; Brain development; Tanycytes; Bergmann glia; Neurogenic niche; Type B cells; Neuroblast; Parkinson's disease; Alzheimer's disease; Amyotrophic lateral sclerosis. |
| Ano: 2012 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000300006 |
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| Menezes,J.R.L.; Marins,M.; Alves,J.A.J.; Fróes,M.M.; Hedin-Pereira,C.. |
| New neurons are constantly added to the olfactory bulb of rodents from birth to adulthood. This accretion is not only dependent on sustained neurogenesis, but also on the migration of neuroblasts and immature neurons from the cortical and striatal subventricular zone (SVZ) to the olfactory bulb. Migration along this long tangential pathway, known as the rostral migratory stream (RMS), is in many ways opposite to the classical radial migration of immature neurons: it is faster, spans a longer distance, does not require radial glial guidance, and is not limited to postmitotic neurons. In recent years many molecules have been found to be expressed specifically in this pathway and to directly affect this migration. Soluble factors with inhibitory, attractive... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Postnatal neurogenesis; Chain migration; Rostral migratory stream; Astrocytes; Gap junctions; Radial glia. |
| Ano: 2002 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002001200002 |
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