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	Provedor de dados BABT (2) Autor Akanji,Akinkunmi Ganiyu (1) Araújo,Elaine Bortoletti de (1) Bishop,Mike (1) Caldeira Filho,José de Souza (1) Couto,Renata Martinussi (1) Frier,Malcolm (1) Hopper,Melanie (1) Muramoto,Emiko (1) Murray,Andrea (1) Perkins,Alan (1) Mais... Palavra-chave Radioimmunotherapy (2) Anti-CD20 (1) Antibody (1) Bladder cancer (1) Monoclonal antibody (1) Radioioactivity (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2005 (1) 2002 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Antibody conjugate radioimmunotherapy of superficial bladder cancer BABT Perkins,Alan; Hopper,Melanie; Murray,Andrea; Frier,Malcolm; Bishop,Mike. The administration of antibody conjugates for cancer therapy is now proving to be of clinical value. We are currently undertaking a programme of clinical studies using the monoclonal antibody C595 (IgG3) which reacts with the MUC1 glycoprotein antigen that is aberrantly expressed in a high proportion of bladder tumours. Radioimmunoconjugates of the C595 antibody have been produced with high radiolabelling efficiency and immunoreactivity using Tc-99m and In-111 for diagnostic imaging, and disease staging and the cytotoxic radionuclides Cu-67 and Re-188 for therapy of superficial bladder cancer. A Phase I/II therapeutic trail involving the intravesical administration of antibody directly into the bladder has now begun. Tipo: Info:eu-repo/semantics/article Palavras-chave: Antibody; Radioimmunotherapy; Bladder cancer. Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132002000500012 Radiolabeling and biodistribution of monoclonal antibody (MAb) anti-CD20 with iodine-131 BABT Akanji,Akinkunmi Ganiyu; Muramoto,Emiko; Caldeira Filho,José de Souza; Couto,Renata Martinussi; Araújo,Elaine Bortoletti de. Radioactive isotopes of iodine, mainly iodine-131 have been broadly used in many monoclonal antibody radioiodination settings, employing different methods. In this study, using a Chloramine-T procedure, the influence of incubation time, CT mass, and Ab/activity ratio on the radiochemical yield of the anti-CD20 antibody labeled with iodine-131 was observed. Radiochemical yield was > 97 %, employing different Chloramine-T masses, independently of incubation time. Radiochemical purity was above 99 % after purification of the labeled compound. The relationship between Ab mass and radioactivity was tested and no difference was observed when 90.6 MBq (2.45mCi) of activity was incorporated in the Ab-mass range studied. Biodistribution study in normal Swiss... Tipo: Info:eu-repo/semantics/article Palavras-chave: Monoclonal antibody; Radioioactivity; Anti-CD20; Radioimmunotherapy. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700010 Registros recuperados: 2 Primeira ... 1 ... Última

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