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| Registros recuperados: 163 | |
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| Pereira-Junior,Pedro P.; Marocolo,Moacir; Rodrigues,Fabricio P.; Medei,Emiliano; Nascimento,José H.M.. |
| Heart rate variability (HRV) analysis consists in a well-established tool for the assessment of cardiac autonomic control, both in humans and in animal models. Conventional methods for HRV analysis in rats rely on conscious state electrocardiogram (ECG) recording based on prior invasive surgical procedures for electrodes/transmitters implants. The aim of the present study was to test a noninvasive and inexpensive method for ECG recording in conscious rats, assessing its feasibility for HRV analysis. A custom-made elastic cotton jacket was developed to fit the rat's mean thoracic circumference, with two pieces of platinum electrodes attached on its inner surface, allowing ECG to be recorded noninvasively in conscious, restrained rats (n=6). Time- and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Electrocardiography; Heart rate variability; Methodology; Noninvasive; Rat. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652010000200019 |
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| BAYIR,YASIN; UN,HARUN; CADIRCI,ELIF; AKPINAR,EROL; DIYARBAKIR,BUSRA; CALIK,ILKNUR; HALICI,ZEKAI. |
| Abstract Our aim is to investigate the potentially preventive effects of Aliskiren in a carrageenan-induced lung pleurisy model and to compare the standard anti-inflammatory agents, indomethacin and dexamethasone. The pleurisy model was induced through the injection of carrageenan (0.2 ml-%2) into the pleural cavity. After the experiment, serum and lung tissues were collected and biochemical, molecular and pathological examinations were performed. In our study, pleural inflammation decreased superoxide dismutase activity and the glutathione level and increased the malondialdehyde level in the lung of rats, while Aliskiren increased the superoxide dismutase activity and glutathione level and decreased the malondialdehyde level. In addition,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Aliskiren; Cytokines; Lung injury; Oxidative stress; Pleurisy; Rat. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000100801 |
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| Scorza,Fulvio A.; Arida,Ricardo M.; Naffah-Mazzacoratti,Maria da Graça; Scerni,Débora A.; Calderazzo,Lineu; Cavalheiro,Esper A.. |
| The systemic administration of a potent muscarinic agonist pilocarpine in rats promotes sequential behavioral and electrographic changes that can be divided into 3 distinct periods: (a) an acute period that built up progressively into a limbic status epilepticus and that lasts 24 h, (b) a silent period with a progressive normalization of EEG and behavior which varies from 4 to 44 days, and (c) a chronic period with spontaneous recurrent seizures (SRSs). The main features of the SRSs observed during the long-term period resemble those of human complex partial seizures and recurs 2-3 times per week per animal. Therefore, the pilocarpine model of epilepsy is a valuable tool not only to study the pathogenesis of temporal lobe epilepsy in human condition, but... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hippocampus; Pilocarpine; Temporal lobe epilepsy; Rat. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652009000300003 |
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| Pinto,M.C.L.; Melo,M.M.; Costa,M.E.R.; Labarrere,C.R.. |
| The hematological and biochemical profiles of newly weaned rats submitted to experimental poisoning with T. serrulatus venom were evaluated. Fifteen recently weaned male Wistar rats (mean weight 130g) were distributed into three equal groups (n = 5). Animals in the control group (group A) received a subcutaneous injection of 400μL of ultra-pure water, while those in the experimental groups received, by identical route, 400μL of a solution containing 100μg (group B) or 450μg (group C) of scorpion venom dissolved in ultra-pure water. Red blood cells indexes, and differential leukocyte and total platelet counts were determined, together with levels of serum glucose, urea, creatinine, lactic dehydrogenase, aspartate aminotransferase, amylase, insulin, and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Rat; Tityus serrulatus; Scorpion; Experimental envenoming; Hematology; Biochemestry. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352010000200015 |
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| Serakides,R.; Nunes,V.A; Nascimento,E.F.; Serra,G.V.. |
| The influence of the estrous cycle on the thyroid gland was studied. Twenty one five-to-seven-month-old Wistar female rats were divided according to the stage of the estrous cycle in two groups: metaestrus-diestrus and proestrus-estrus. After gross inspection, the thyroids were weighed, sampled, and processed for staining with hematoxilyn-eosin. Seric concentrations of total T4, free T4, total T3, TSH, progesterone, and estradiol were measured. The values of estradiol were significantly higher in the proestrus-estrus stage. However, no significant differences in the plasmatic concentrations of progesterone, free T4, total T4 and TSH throughout the cycle were found. The results of the morphometric study of the thyroid did not indicate any significant... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Rat; Thyroid; Estrous cycle. |
| Ano: 2002 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352002000100017 |
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| Martins,D.B; Lopes,S.T.A; Mazzanti,C.M; Spanevello,R; Schmatz,R; Corrêa,M; Stefanello,N; Schetinger,M.R; Morsch,V; Veiga,A.P.M. |
| Brain and serum lipid peroxidation was studied in rats treated with vincristine sulphate and different doses of nandrolone decanoate. Thirty rats were distributed into six groups (n=5). The treatments were applied once a week for two weeks. Sample collection was performed in the third week. Treatments during the first week were: G1 (control) - physiologic solution, G2 - vincristine sulphate (4mg/m²), G3 - physiologic solution, G4 - physiologic solution, G5- vincristine sulphate (4mg/m²), and G6 - vincristine sulphate (4mg/m²). In the second week, they were: G1 (control) - physiologic solution, G2- physiologic solution, G3 - nandrolone decanoate (1.8mg/kg-1), G4 - nandrolone decanoate (10mg/kg-1), G5 - nandrolone decanoate (1.8mg/kg-1), and G6 - nandrolone... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Rat; Anabolic androgenic steroid; Chemotherapeutic; Free radicals; Brain; Blood serum. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352011000100017 |
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| Araújo,F.R.G.; Castro,C.M.M.B.; Severo,M.S.; Diniz,M.F.A.; Viana,M.T.; Evêncio,L.B.. |
| Identificou-se a microbiota normal da região peri-alveolar de incisivos em 72 ratos Wistar, com 70-90 dias de idade e 280-330g de peso. As bactérias foram coletadas com suabes embebidos em solução salina. Do material depositado em tubo contendo 460µl de Brain Heart Infusion e diluído em 1:10, retirou-se 1µl para semeadura em placas de Petri. O crescimento médio foi 1,4x10(6) ± 2,6x10(5)UFC/ml. Segundo a ordem das freqüências, as bactérias encontradas foram: Bacillus sp., Staphylococcus aureus, Streptococcus viridans, Corynebacterium sp., Staphylococcus coagulase negativa, Enterococcus sp., Staphylococcus saprophyticcus, Escherichia coli, Klebsiella oxytoca, Klebsiella pneumoniae e Serratia liquefaciens. De todas as bactérias isoladas, as Gram-positivas e... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Rat; Microbiota; Aerobic bacteria; Perialveolar region; Alveoliti. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352007000600037 |
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| Serakides,R.; Ribeiro,A.F.C.; Silva,C.M.; Santos,R.L.; Nunes,V.A.; Nascimento,E.F.. |
| The objective of this report was to describe the pathological changes in the urinary bladder of female rats naturally infected with Trichosomoides crassicauda. Forty eight 5 to 8 months of age female Wistar rats were studied. At necropsy uroliths were detected in seven animals (14.6%). Among the bladders that contained the parasite only three (6.3%) did not show any significant histological change and were considered normal, but on the contrary, three (6.3%) did contain papillomas and uroliths, four (8.3%) had uroliths associated with epithelial hyperplasia ranging from moderate to severe, and the remaining (79.2%) showed variable degrees of epithelial hyperplasia and inflammation without urolithiasis. It cannot be concluded whether irritation of the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Rat; Urinary bladder; Trichosomoides crassicauda; Urolith; Papilloma. |
| Ano: 2001 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352001000200012 |
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| Buchaim,R.L.; Andreo,J.C.; Rodrigues,A. C.; Buchaim,D.V.; Dias,D.V.; Daré,L.R.; Roque,D.D.; Roque,J.S.. |
| The objective of this study was to evaluate whether demineralized bovine bone (Gen-ox®) alters bone neoformation in rats submitted to alcoholism. Forty male rats were separated into two groups of 20 rats and distributed as follows: Group E1, which received 25% ethanol and a surgical cavity filled only by a blood clot, and Group E2, which received 25% ethanol and a surgical cavity filled with Gen-ox®. The animals were euthanized at 10, 20, 40 and 60 days after surgery and necropsy was performed. The histomorphological and histometric analyses of the area of connective tissue and bone neoformation showed that the reorganization of the bone marrow and full repair of the surgical cavity in Group E1 occurred more quickly than in Group E2. It was also noted that... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Rat; Bone regeneration; Alcoholism. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352013000300016 |
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| Bicalho,K.A.; Araújo,F.T.M.; Rocha,R.S.; Carvalho,O.S.. |
| The sanitary conditions of 13 animal houses in nine public institutions in Minas Gerais, and the presence of endo and ectoparasites of mice and rats colonies kept in these facilities were evaluated. Data about barriers to prevent the transmission of diseases and a program of sanitary monitoring were obtained through a questionnaire and local visit. Parasitological methods were performed for diagnosing mite, lice, helminthes, and protozoa parasites in 344 mice and 111 rats. Data have shown that the majority of the animal houses had neither proper physical environment nor protection barriers to prevent the transmission of infections. Parasitological results have shown that only one animal house (7.7%) had parasite free animals, whereas the others have... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Mice; Rat; Animal house; Parasite; Sanitary barrier. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352007000600020 |
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| Oliveira,K.P.; Reis,A.M.S.; Silva,A.P.; Silva,C.L.R.; Goes,A.M.; Serakides,R.; Ocarino,N.M.. |
| ABSTRACT The objective was to evaluate the in vitro effect of prolactin in osteogenic potential of adipose tissue-derived mesenchymal stem cells (ADSCs) in female rats. ADSCs were cultured in osteogenic medium with and without the addition of prolactin and distributed into three groups: 1) ADSCs (control), 2) ADSCs with addition of 100ng/mL of prolactin and 3) ADSCs with addition of 300ng/mL of prolactin. At 21 days of differentiation, the tests of MTT conversion into formazan crystals, percentage of mineralized nodules and cells per field and quantification of genic transcript for alkaline phosphatase, osteopontin, osteocalcin, bone sialoprotein, BMP-2 and collagen I by real-time RT-PCR were made. The addition of prolactin reduced the conversion of MTT in... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Rat; Osteogenic differentiation; Osteoblasts; Hormone; Adipose tissue. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352017000601573 |
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| Castro,A.C.S.; Queiroz,G.F.; Nogueira,J.C.; Coimbra,C.C.; Reis,A.M.; Marubayashi,U.; Yamasaki,K.. |
| The objectives of this study were to evaluate the effects of pinealectomy, adrenalectomy and pinealectomy-adrenalectomy upon the quantification of spermatogenic cells of rats. As such, 32 adult Wistar rats with a mean body weight of 331.7± 15.5g were assigned into one of the following treatments: (a) a sham-operated control group, consisting of nine animals; (b) ten pinealectomized animals; (c) seven adrenalectomized animals and (d) six pinealectomized plus adrenalectomized animals. No significant differences were observed between groups for the following parameters: body, testes, prostate and seminal vesicle weights, seminiferous tubular diameter, number of cells per seminiferous tubular cross sections (primary spermatocytes at pachytene, round... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Spermatogenesis; Pinealectomy; Adrenalectomy; Rat. |
| Ano: 2002 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352002000300008 |
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| Fialho,L.; Rafael,A.; Cabrita,A.S.; Pereira,A.M.F.; Capela e Silva,F.. |
| Avaliou-se o efeito do tirame, ditiocarbamato largamente utilizado na agricultura como antifúngico e repelente de roedores, na ossificação endocondral de mamíferos, usando, como modelo, ratos Wistar. Não foram observadas lesões na cartilagem articular, nem nas placas de crescimento, o que pode ser atribuído à dose utilizada e à duração do ensaio. A diminuição da altura da placa de crescimento nos animais aos quais foi administrado o tirame parece traduzir o atraso verificado no crescimento em geral, e não um efeito específico na cartilagem, uma vez que as diferentes zonas da placa epifisária mantiveram as proporções dos animais do grupo-controle. Embora não tenham sido verificados, no presente trabalho, os efeitos registrados para outras espécies nos... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Rat; Dithiocarbamate; Thiram; Growth plate; Articular cartilage. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352012000100036 |
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| Ocarino,N.M.; Bozzi,A.; Pereira,R.D.O.; Breyner,N.M.; Silva,V.L.; Castanheira,P.; Goes,A.M.; Serakides,R.. |
| 4&', 6-diamidino-2-phenylindole dihydrochloride (DAPI) is a DNA dye widely used to mark and trace stem cells in therapy. We here studied the effect of DAPI staining on the behavior of mesenchymal stem cells cultured in either a control, non-osteogenic medium or in an osteogenic differentiation medium. In the control medium, the number of stem cells/field, as well as the number of fluorescent cells/field increased up to the sixth day in both control and DAPI-treated cultures. Afterwards, both the number of fluorescent cells and their fluorescence intensity decreased. Control cells were fusiform and with some long extensions that apparently linked them to neighboring cells, while DAPI-treated cells were mostly round cells with fine and short extensions.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Bone marrow; Cell cultures; Rat; Osteogenic differentiation. |
| Ano: 2008 |
URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452008000200003 |
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| HAMAME,CARLOS M; DELANO,PAÚL H; ROBLES,LUIS. |
| Twelve rats were trained to perform a two-choice visual detection task in which a right or left light was presented and the animáis were required to press the lever located under the illuminated light for a food reward. In seventy percent of the triáis the target light was preceded by presentation of a neutral cue (a central light). Relevance of the neutral cue for detection of the target was analyzed by comparing behavioral Índices of attention in its presence and absence. Accuracy was significantly higher in presence than in absence of the neutral cue, while mean response latencies were lower in presence than in absence of the neutral cue. These results indicate that the animáis allocated attentional resources on the target detection during a high... |
| Tipo: Journal article |
Palavras-chave: Alerting effect; Attention; Detection task; Expectancy; Neutral cue; Rat. |
| Ano: 2008 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602008000400012 |
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| Zhao,Liping; Yan,Wenhui; Xiang,Heng; Wang,Xiaoyang; Qiao,Haixuan. |
| The mechanisms of exercise-induced fatigue have not been investigated using proteomic techniques, an approach that could improve our understanding and generate novel information regarding the effects of exercise. In this study, the proteom alterations of rat skeletal muscle were investigated during exercise-induced fatigue. The proteins were extracted from the skeletal muscle of SD rat thigh, and then analyzed by two-dimensional electrophoresis and PDQuest software. Compared to control samples, 10 significantly altered proteins were found in exercise samples, two of them were upregulated and eight of them were downregulated. These proteins were identified by MALDI TOF-MS. The two upregulated proteins were identified as MLC1 and myosin L2 (DTNB) regulatory... |
| Tipo: Journal article |
Palavras-chave: Proteomics; Exercise-induced fatigue; Skeletal muscle; Rat. |
| Ano: 2012 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000100010 |
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| PEÑARROJA-MATUTAN0,C; PARADA-BUSTAMANTE,A; ORIHUELA,P A; RÍOS,M; VELASQUEZ,LUIS A; CROXATTO,H B. |
| Estradiol (E2) accelerates oviductal egg transport through nongenomic pathways involving oviductal protein phosphorylation in non-mated rats, and through genomic pathways in mated rats. Here we investigated the ability of cervico-vaginal stimulation (CVS) to switch the mode of action of E2 in the absence of other male-associated components. Pro-estrous rats were subjected to CVS with a glass rod and 12 hours later were injected subcutaneously with E2 and intrabursally with the RNA synthesis inhibitor Actinomycin D or the protein phosphorylation inhibitor H-89. The number of eggs in the oviduct, assessed 24 h later, showed that Actinomycin D, but not H-89 blocked the E2-induced egg transport acceleration. This clearly indicates that CVS alone, without other... |
| Tipo: Journal article |
Palavras-chave: Mating; Oviduct; Estradiol; Signaling pathways; Prolactin receptor; Egg transport; Rat. |
| Ano: 2007 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602007000200012 |
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| Registros recuperados: 163 | |
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