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Short-term levosimendan treatment protects rat testes against oxidative stress BJMBR
Yuksel,M.B.; Kavak,S.; Gecit,I.; Basel,H.; Gümrükçüoğlu,H.A.; Demir,H.; Meral,İ..
The objective of this study was to evaluate the effect of short-term levosimendan exposure on oxidant/antioxidant status and trace element levels in the testes of rats under physiological conditions. Twenty male Wistar albino rats were randomly divided into two groups of 10 animals each. Group 1 was not exposed to levosimendan and served as control. Levosimendan (12 µg/kg) diluted in 10 mL 0.9% NaCl was administered intraperitoneally to group 2. Animals of both groups were sacrificed after 3 days and their testes were harvested for the determination of changes in tissue oxidant/antioxidant status and trace element levels. Tissue malondialdehyde (MDA) was significantly lower in the levosimendan group (P < 0.001) than in the untreated control group and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Levosimendan; Oxidative stress; Reactive oxygen species; Rat testes; SOD; GSH-Px; MDA.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000800005
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