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| Registros recuperados: 135 | |
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| CORVINO,SILVANA B.; DAMASCENO,DÉBORA C.; SINZATO,YURI K.; NETTO,ALINE O.; MACEDO,NATHÁLIA C.D.; ZAMBRANO,ELENA; VOLPATO,GUSTAVO T.. |
| ABSTRACT The aim of this study was to compare two models of swimming applied to pregnant rats born small for pregnancy age (SPA). Diabetes was chemically induced in adult female rats to develop an inadequate intrauterine environment, leading to birth of a SPA offspring. In adulthood, the female SPA rats were mated and submitted to different swimming programs. The exercise program 1 (Ex1) consisted of swimming for 15 minutes, followed by 15 minutes of rest and another 15 minutes of swimming, 3 days a week before and during pregnancy. Another program (Ex2) was applied during 60 minutes uninterrupted a day, 6 days/week during pregnancy. The pregnant rats presented no interference on body weight and glycemia. The rats submitted to Ex2 model showed decreased... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Rats; Diabetes; Pregnancy; Offspring; Exercise.. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000100223 |
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| SALVATIERRA,CRISTIANA S.B.; REIS,SÍLVIA R.L.; PESSOA,ANA F.M.; SOUZA,LETÍCIA M.I. DE; STOPPIGLIA,LUIZ F.; VELOSO,ROBERTO V.; REIS,MARISE A.B.; CARNEIRO,EVERARDO M.; BOSCHERO,ANTONIO C.; COLODEL,EDSON M.; ARANTES,VANESSA C.; LATORRACA,MÁRCIA Q.. |
| The phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways mediate β cell growth, proliferation, survival and death. We investigated whether protein restriction during pregnancy alters islet morphometry or the expression and phosphorylation of several proteins involved in the phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways. As controls, adult pregnant and non-pregnant rats were fed a normal-protein diet (17%). Pregnant and non-pregnant rats in the experimental groups were fed a low-protein diet (6%) for 15 days. Low protein diet during pregnancy increased serum prolactin level, reduced serum corticosterone concentration and the expression of both protein kinase B/AKT1 (AKT1) and p70 ribosomal protein S6... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: MAP kinase pathway; Pancreatic islets; PI3K pathway; Pregnancy; Protein restriction; Rats. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000201007 |
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| MAGALHÃES,DIEGO A. DE; KUME,WILLIAN T.; CORREIA,FRANCYELE S.; QUEIROZ,THAÍS S.; ALLEBRANDT NETO,EDGAR W.; SANTOS,MAÍSA P. DOS; KAWASHITA,NAIR H.; FRANÇA,SUÉLEM A. DE. |
| Our objective was to establish a diabetes mellitus type 2 (DM2) model in rats using a high-fat diet and streptozotocin (HF-STZ). Male Wistar rats (240-250g) were divided into a control group (commercial feed), and HF-STZ group, (66.5%-commercial feed, 13.5%-lard, and 20%-sugar). STZ (40mg/kg i.p.) or vehicle was administered on the 13th day. An oral glucose tolerance test (OGTT) was performed (2.5mg of glucose/kg v.o.) on both groups. After 39 days of treatment, blood and tissue samples were collected for analyses. The weight gain after STZ administration was lower in the HF-STZ group than in the control group with reductions in muscle mass and adipose tissue. The HF-STZ group showed hyperglycemia after STZ administration (glucose on day 39: HF-STZ: 499 ±... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Diabetes mellitus type 2 model; High-fat diet; Streptozotocin; Rats. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000100615 |
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| NETTO,ALINE OLIVEIRA; MACEDO,NATHÁLIA C.D.; GALLEGO,FRANCIANE Q.; SINZATO,YURI K.; VOLPATO,GUSTAVO T.; DAMASCENO,DÉBORA C.. |
| ABSTRACT Several studies present different methodologies and results about intensity exercise, and many of them are performed in male rats. However, the impact of different type, intensity, frequency and duration of exercise on female rats needs more investigation. From the analysis of blood lactate concentration during lactate minimum test (LacMin) in the swimming exercise, the anaerobic threshold (AT) was identified, which parameter is defined as the transition point between aerobic and anaerobic metabolism. LacMin test is considered a good indicator of aerobic conditioning and has been used in prescription of training in different exercise modalities. However, there is no evidence of LacMin test in female rats. The objective was to determine AT in... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Exercise; Swimming; Anaerobic threshold; Lactate; Pregnancy; Rats. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000602749 |
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| TRONCHINI,ELEANDRO A.; TREVIZAN,ALINE R.; TASHIMA,CRISTIANO M.; FREITAS,PRISCILA DE; BAZOTTE,ROBERTO B.; PEREIRA,MARLI A.S.; ZANONI,JACQUELINE N.. |
| The objective of this work was to investigate the effect of the L-glutamine supplementation to prevent - diabetes induced changes in myenteric neurons and also to verify the effect on the mucosa of the ileum of Wistar rats. The animals were divided in five groups (n = 5): untreated normoglycaemic (UN), normoglycaemic treated with L-glutamine (NG), untreated diabetics (UD), diabetics treated with L-glutamine, starting on the 4th (DG4) or 45thday following diabetes induction (DG45). The amino acid was added to the diet at 1%. The density and size of neurons, the metaphasic index in the crypt, the height of the villus, the depth of the crypt and the number of globet cells were determined. There was no difference in the neuronal density and in the cellular... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Diabetes mellitus; L-glutamine; Myenteric plexus; Myosin-V; Rats. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652013000301165 |
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| RESENDE,NATHÁLIA M.; FÉLIX,HENRIQUE R.; SORÉ,MURILLO R.; M.M. NETO,ANÍBAL; CAMPOS,KLEBER E.; VOLPATO,GUSTAVO T.. |
| This study aims to verify the effects of coconut oil supplementation (COS) in the body composition and lipid profile of rats submitted to physical exercise. The animals (n=6 per group) were randomly assigned to: G1=Sedentary and Non-supplemented (Control Group), G2=Sedentary and Supplemented, G3=Exercised and Non-supplemented and G4=Exercised and Supplemented. The COS protocol used was 3 mL/Kg of body mass by gavage for 28 days. The physical exercise was the vertical jumping training for 28 days. It was determined the body mass parameters, Lee Index, blood glucose and lipid profile. The COS did not interfere with body mass, but the lean body mass was lower in G3 compared to G2. The final Lee Index classified G1 and G2 as obese (>30g/cm). The lipid... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cocos nucifera; LDL-c/HDL-c ratio; Lipid profile; Nutrition; Rats; Vertical jumping training. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000300933 |
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| Miranda,Amarildo; Costa-e-Sousa,Ricardo H.; Werneck-de-Castro,João P.S.; Mattos,Elisabete C.; Olivares,Emerson L.; Ribeiro,Vanessa P.; Silva,Márcia G.; Goldenberg,Regina C.S.; Campos-de-Carvalho,Antônio C.. |
| In animal models the evaluation of myocardial infarct size in vivo and its relation to the actual lesion found post mortem is still a challenge. The purpose of the current study was to address if the conventional electrocardiogram (ECG) and/or echocardiogram (ECHO) could be used to adequately predict the size of the infarct in rats. Wistar rats were infarcted by left coronary ligation and then ECG, ECHO and histopathology were performed at 1, 7 and 28 days after surgery. Correlation between infarct size by histology and Q wave amplitude in lead L1 was only found when ECGs were performed one day post-surgery. Left ventricular diastolic and systolic dimensions correlated with infarct size by ECHO on day 7 post-infarction. On days 7 and 28 post-infarction,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Myocardial infarction; Rats; Electrocardiogram; Echocardiogram; Infarct size. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652007000400006 |
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| Reis,A.M.S.; Oliveira,K.P.; Paula,I.H.F.; Silva,A.P.; Tarragô,J.F.; Ocarino,N.M.; Serakides,R.. |
| ABSTRACT The aim of this study was to evaluate the effect of concentrations of caffeine on the viability, synthesis activity and gene expression in cultures of chondrocytes. Extracted articular cartilage from the femurs and tibias of 15 Wistar rats at three days old to isolate chondrocytes. Chondrocytes were cultured in chondrogenic medium (control) or supplemented with caffeine (0.5, 1.0, 2.0mM). Cell viability, alkaline phosphatase activity and collagen synthesis were assessed using colorimetric assays at 7, 14, 21 days. The chondrocyte cultures of all groups grown under coverslips were stained with hematoxylin-eosin to determine the percentage of cells/field and with PAS, safranin O, alcian blue to determine the percentage of matrix chondrogenic/field... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Rats; Caffeine; Chondrocytes; Chondrogenesis. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352019000200509 |
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| Sánchez Negrette,M; Montenegro,M.A.; Catuogno,M.S.; Lértora,W.J.; Guanziroli,M.C.. |
| Epidemiological studies in human beings and experimental studies in laboratory animals suggest that milk and dairy products can inhibit effects on the development of some kinds of tumors. Cow milk contains sphingomyelin, butyric acid, conjugated linoleic acid, calcium, vitamin A, carotene and vitamin D. All of these components are known to inhibit the process of carcinogenesis. Our objective was to determine the effect of cow milk and water buffalo milk on the development of colon neoplasias in an experimental model of carcinogenesis in rats induced with 1,2-dimethylhydrazine (DMH). Three-month-old Wistar male rats with an average body weight of 180 g were given a nutritionally adequate diet and drinking water adlivitum, cow milk or water buffalo milk. The... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Intestinal cancer; Milk; Cow milk; Buffalo milk; DMH; Rats. |
| Ano: 2007 |
URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452007000300005 |
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| AJDANOVI,VLADIMIR Z; OI-JURJEVI,BRANKA T; FILIPÓVI,BRANKO R; TRIFUNOVI,SVETLANA L; BRKIC,DEJAN D; SEKULI,MILKA I; MILOSEVI,VERICA LJ. |
| The soybean phytoestrogen, genistein, is increasingly consumed as an alternative therapeutic for age-related diseases, namely cardiovascular conditions, cancer and osteoporosis. However, despite the beneficial effects on health, concern has been raised that this isoflavone also acts as an endocrine-disrupting chemical. The aim of this study was to examine the effects of genistein on immunohistomorphometric features of pituitary adrenocorticotropic cells (ACTH) and blood concentrations of ACTH and corticosterone in orchidectomized middle-aged male rats. Sixteen-month-old Wistar rats were divided into sham-operated (SO), orchidectomized (Orx) and genistein-treated orchidectomized (Orx+G) groups. Genistein (30mg/kg/day) was administered subcutaneously for... |
| Tipo: Journal article |
Palavras-chave: ACTH cells; Corticosterone; Genistein; Middle-age; Orchidectomy; Rats. |
| Ano: 2009 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602009000100002 |
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| NASCIMENTO,ANDRÉ F; SUGIZAKI,MÁRIO M; LEOPOLDO,ANDRÉ S; LIMA-LEOPOLDO,ANA P; NOGUEIRA,CÉLIA R; NOVELLI,ETHEL L. B; PADOVANI,CARLOS R; CICOGNA,ANTONIO C. |
| The aim of the present study was to determine the classification error probabilities, as lean or obese, in hypercaloric diet-induced obesity, which depends on the variable used to characterize animal obesity. In addition, the misclassification probabilities in animáis submitted to normocaloric diet were also evaluated. Male Wistar rats were randomly distributed into two groups: normal diet (ND; n=31; 3,5 Kcal/g) and hypercaloric diet (HD; n=31; 4,6 Kcal/g). The ND group received commercial Labina rat feed and HD animáis a cycle of five hypercaloric diets for a 14-week period. The variables analysed were body weight, body composition, body weight to length ratio, Lee Índex, body mass Índex and misclassification probability. A 5% significance level was used.... |
| Tipo: Journal article |
Palavras-chave: Diet; Diet-induced obesity; Hypercaloric diet; Misclassification; Rats. |
| Ano: 2008 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602008000300002 |
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| AZARA,CÍNTIA R.P; MAIA,INGRID C; RANGEL,CAROLINA N; SILVA-NETO,MÁRIO A.C; SERPA,RENATA F.B; DE JESUS,EDGAR F.O; TAVARES DO CARMO,MARIA G; FIALHO,ELIANE. |
| Lactating Wistar rats were fed a liquid diet containing either ethanol [ethanol-fed group (EFG)] or an isocaloric amount of carbohydrate [pair-fed group (PFG)] from day 1 postpartum up to day 14 of lactation, to investigate micro/macronutrient milk composition and the mineral status of pups. EFG presented a reduction of daily milk production and milk composition was significantly higher in protein and lower in carbohydrate, while the lipid content was similar to that of PFG. When compared to PFG, the milk of EFG had a decreased proportion of C22:6 n-3 fatty acid and an increase in medium-chain fatty acids and of several minerals. Pups of EFG showed reduced growth and a lower concentration of Cu and Sr in plasma and lower concentrations of Ca, P and Cl, and... |
| Tipo: Journal article |
Palavras-chave: Breast milk; Ethanol; Rats; Lactation; Minerals status and milk composition. |
| Ano: 2008 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602008000300008 |
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| MOSELHY,SAID S; ALI,HUSEIN K. H. |
| Cinnamon is used to flavor most foods in Arabian countries. The aim of this study was to evaluate the medicinal importance, reflecting an important trend in research. The hepatoprotective activity of aqueous and ethanolic extracts of cinnamon was investigated against carbon tetrachloride (CC1(4)) induced lipid peroxidation and hepatic injury in rats. The elevated serum AST and ALT enzymatic activities induced by CC1(4) were significantly restored to near normal by oral administration of 200 mg/kg of either extracts once daily for 7 days, as compared to untreated rats. There was a significant elevation in the level of liver malondialdhyde (MDA), while the activities of antioxidant enzymes superoxide dismutase and catalase (SOD and CAT) were significantly... |
| Tipo: Journal article |
Palavras-chave: Cinnamon extracts; CCL; Oxidative stress; Rats. |
| Ano: 2009 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602009000100009 |
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| Teixeira,Gerlinde Agate Platais Brasil; Antunes,Danielle Mota Fontes; Castro Júnior,Archimedes Barbosa de; Costa,Janilda Pacheco da; Paschoal,Patrícia Olaya; Campos,Sylvia Maria Nicolau; Pedruzzi,Monique de Morais Bitetti; Araújo,Vinicius da Silva; Andrade,Luis Antônio Botelho; Moreno,Silvana Ramos Farias; Nobrega,Alberto Felix Antonio da; Cardoso,Gilberto Perez. |
| Food allergy is an adverse reaction that occurs in susceptible people when they eat sensitizing foods and is one of the causes of Inflammatory Bowel Disease (IBD). The effort to understand the induction process of these diseases is important as IBD is increasing worldwide, including in Brazil. The aim of this study was to develop an experimental antigen specific inflammatory process of the gut of mice and rats, using peanut seeds. Animals were immunized with peanut protein extract before their exposure to the in natura peanut seeds. Results showed that systemic immunization with peanut protein extracts rendered significantly higher antibody titers than control groups and that immunized animals submitted to a challenge diet containing peanuts presented time... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Food allergy; Peanuts; Inflammatory bowel disease; Rats; Mice. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132009000300012 |
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| Oliveira,Denise Silva de; Amado,Ciomar Aparecida Bersani; Martini,Mirian Carvalho; Suzuki-Kemmelmeier,Fumie; Bracht,Adelar. |
| Glycogen levels and the energy status of livers from fasting rats with diabetes types 1 and 2 were measured. After a 24 h fast, the hepatic glycogen levels of rats with diabetes1 and diabetes2 were, 18.7 and 2.6 times higher, respectively, than those of livers from the normal rats. In diabetes1 rats, the glycogen levels decreased when the fasting period was extended to 48 and 72 h. The opposite occurred with the control and diabetes2 rats. Consistently, glucose release by the perfused livers from diabetes1 rats was considerably higher during at least 60 minutes after initiating perfusion. The hepatic ATP content of diabetes1 rats was similar to that of the control rats; in diabetes2 rats, the hepatic ATP content was increased. It could be concluded that... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Diabetes type 1; Diabetes type 2; Rats; Hepatic glycogen; Hepatic energy status. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132007000500006 |
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| Registros recuperados: 135 | |
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