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	Provedor de dados Electron. J. Biotechnol. (1) Autor Etcheverrigaray,Marina (1) Forno,Guillermina (1) Kratje,Ricardo (1) Marini,Guillermo (1) Palavra-chave Glycosylation (1) Pharmacokinetic parameters (1) RhGM-CSF (1) Tipo do documento Journal article (1) Ano 2007 (1) País Chile (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Recombinant human granulocyte-macrophage colony-stimulating factor: effect of glycosylation on pharmacokinetic parameters Electron. J. Biotechnol. Marini,Guillermo; Forno,Guillermina; Kratje,Ricardo; Etcheverrigaray,Marina. The pharmacokinetic behaviour of the non-glycosylated, bacterially-derived recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) and the glycosylated mammalian product was studied after intra and extra vascular administration of a single dose in rodents. Each route of administration gave a different rhGM-CSF concentration-time profile. After extra vascular administration of equivalent doses, a higher peak concentration and faster elimination were observed in the group treated with the E. coli-derived cytokine. The faster elimination resulted in a return to pre-treatment plasma levels after 12 hrs, versus 48 hrs following the administration of glycosylated rhGM-CSF. After intravascular administration, clearance of rhGM-CSF was... Tipo: Journal article Palavras-chave: Glycosylation; Pharmacokinetic parameters; RhGM-CSF. Ano: 2007 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582007000200011 Registros recuperados: 1 Primeira ... 1 ... Última

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