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| Matic,Sanja; Stanic,Snezana; Bogojevic,Desanka; Solujic,Slavica; Grdovic,Nevena; Vidakovic,Melita; Mihailovic,Mirjana. |
| The intention was to evaluate the possible in vivo genotoxic potential in different cell-types, of a methanol extract obtained from the plant stem of Cotinus coggygria Scop., using the sex-linked recessive lethal (or SLRL) test and alkaline comet assay. The SLRL test, revealed the genotoxic effect of this extract in postmeiotic and premeiotic germ-cell lines. The comet assay was carried out on rat liver and bone marrow at 24 and 72 h after intraperitoneal administration. For genotoxic evaluation, three concentrations of the extract were tested, viz., 500, 1000 and 2000 mg/kg body weight (bw), based on the solubility limit of the extract in saline. Comet tail moment and total scores in the group treated with 500 mg/kg bw, 24 and 72 h after treatment, were... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Comet assay; Cotinus coggygria; Extract; Genotoxic effect; SLRL. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000200022 |
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