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| FRANCHI,LEONARDO P.; GUIMARAES,NILZA N.; ANDRADE,LAISE R. DE; ANDRADE,HELOISA H.R. DE; LEHMANN,MAURICIO; DIHL,RAFAEL R.; CUNHA,KENYA S.. |
| Noni, a Hawaiian name for the fruit of Morinda citrifolia L., is a traditional medicinal plant from Polynesia widely used for the treatment of many diseases including arthritis, diabetes, asthma, hypertension and cancer. Here, a commercial noni juice (TNJ) was evaluated for its protective activities against the lesions induced by mitomycin C (MMC) and doxorrubicin (DXR) using the Somatic Mutation and Recombination Test (SMART) in Drosophila melanogaster. Three-day-old larvae, trans-heterozygous for two genetic markers (mwh and flr3 ), were co-treated with TNJ plus MMC or DXR. We have observed a reduction in genotoxic effects of MMC and DXR caused by the juice. TNJ provoked a marked decrease in all kinds of MMC- and DXR-induced mutant spots, mainly due... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antigenotoxicity; Doxorrubicin; Mitomycin C; SMART; Noni juice. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652013000200585 |
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| Sader,Helio S.; Jones,Ronald N.; Ballow,Charles H.; Biedenbach,Douglas J.; Cereda,Rosangela F.. |
| Gram-positive cocci are important causes of both nosocomial and community-acquired infections, and antimicrobial resistance among these pathogens has become an important problem worldwide. Since resistance among these organisms can vary substantially by geographic location, we conducted a multicenter surveillance study with isolates from five Latin American countries (15 medical centers). Quinupristin/dalfopristin (formerly RP-59500) is a novel streptogramin combination with focused activity against Gram-positive cocci, many exhibiting emerging resistance. The in vitro activity of quinupristin/dalfopristin and 12 other antimicrobial agents were evaluated against 1,948 strains including Staphylococcus aureus (747 strains), coagulase-negative staphylococci... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Quinupristin/dalfopristin; Gram-positive cocci; SMART; Antimicrobial surveillance. |
| Ano: 2001 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000100004 |
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| Karlowsky,James A.; Hoban,Daryl J.; Hackel,Meredith A.; Lob,Sibylle H.; Sahm,Daniel F.. |
| ABSTRACT Gram-negative ESKAPE pathogens (Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) are important etiologic agents of nosocomial infection that are frequently resistant to broad-spectrum antimicrobial agents. Gram-negative ESKAPE pathogens were collected from hospitalized patients in 11 Latin American countries from 2013 to 2015 as part of the Study for Monitoring Antimicrobial Resistance Trends (SMART) global surveillance program. In total, 2113 isolates from intra-abdominal infections (IAI) and 970 isolates from urinary tract infections (UTI) were tested against antimicrobial agents using standardized CLSI broth microdilution methodology. Of the agents tested, amikacin demonstrated the highest rates... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Surveillance; SMART; Imipenem; Ertapenem. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000300343 |
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| Dutra,Elaine S.; Dias,Cristina D.; Araújo,Bethânia C. de; Castro,Antônio J. S.; Nepomuceno,Júlio C.. |
| The consumption of organic tomatoes (ORTs) reduces the risk of harmful effects to humans and the environment caused by exposure to toxic agrochemicals. In this study, we used the somatic mutation and recombination test (SMART) of wing spots in Drosophila melanogaster to evaluate the genotoxicity of ORT and the effect of cotreatment with ORT on the genotoxicity of Doxorubicin ® (DXR, a cancer chemotherapeutic agent) that is mediated by free radical formation. Standard (ST) cross larvae were treated chronically with solutions containing 25%, 50% or 100% of an aqueous extract of ORT, in the absence and presence of DXR (0.125 mg/mL), and the number of mutant spots on the wings of emergent flies was counted. ORT alone was not genotoxic but enhanced the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antioxidants; Co-genotoxicity; Drosophila melanogaster; Organic tomato; SMART. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000100020 |
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| Jacociunas,Laura Vicedo; Dihl,Rafael Rodrigues; Lehmann,Mauricio; Ferraz,Alexandre de Barros Falcão; Richter,Marc François; Silva,Juliana da; Andrade,Heloísa Helena Rodrigues de. |
| The genotoxicity of bloom head (BHE) and leaf (LE) extracts from artichoke (Cynara scolymus L.), and their ability to modulate the mutagenicity and recombinogenicity of two alkylating agents (ethyl methanesulfonate - EMS and mitomycin C - MMC) and the intercalating agent bleomycin (BLM), were examined using the somatic mutation and recombination test (SMART) in Drosophila melanogaster. Neither the mutagenicity nor the recombinogenicity of BLM or MMC was modified by co- or post-treatment with BHE or LE. In contrast, co-treatment with BHE significantly enhanced the EMS-induced genotoxicity involving mutagenic and/or recombinant events. Co-treatment with LE did not alter the genotoxicity of EMS whereas post-treatment with the highest dose of LE significantly... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Artichoke; Drosophila melanogaster; Recombinogenicity; SMART. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572014000100015 |
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| Lopes,Jeyson Césary; Machado,Nayane Moreira; Saturnino,Rosiane Soares; Nepomuceno,Júlio César. |
| Pantoprazole® is one of the leading proton pump inhibitors (PPIs) used in the treatment of a variety of diseases related to the upper gastrointestinal tract. However, studies have shown an increased risk of developing gastric cancer, intestinal metaplasia and hyperplasia of endocrine cells with prolonged use. In the present study, the somatic mutation and recombination test (SMART) was employed to determine the mutagenic effects of Pantoprazole on Drosophila melanogaster. Repeated treatments with Pantoprazole were performed on 72-hour larvae of the standard (ST) and high bioactivation (HB) crosses at concentrations of 2.5, 5.0, and 10.0 μM. In addition, doxorubicin (DXR) was administered at 0.4 mM, as a positive control. When administered to ST... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Drosophila melanogaster; Mutagenicity; Proton pump inhibitors; Pantoprazole; Recombinogenicity; SMART. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572015000100101 |
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| Pereira,Denise G.; Antunes,Lusânia M.G.; Graf,Ulrich; Spanó,Mário A.. |
| Panax ginseng is one of the most widely prescribed herbal medicines for the treatment of cancer, diabetes, chronic inflammation, and neurodegenerative and cardiovascular diseases. Since the use of alternative medicines in combination with conventional therapy may increase the risk of unwanted interactions, we investigated the possible genotoxicity of a water-soluble form of the dry root of P. ginseng (2.5, 5.0 or 10.0 mg/mL) and its ability to protect against the genotoxicity of doxorubicin (DOX; 0.125 mg/mL) by using the Drosophila melanogaster wing somatic mutation and recombination test (SMART) with standard and high-bioactivation crosses of flies. Panax ginseng was not genotoxic at the concentrations tested, whereas DOX-induced genotoxicity in... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antigenotoxicity; SMART; Wing spot test. |
| Ano: 2008 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572008000500024 |
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