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Increased expression levels of Syntaxin 1A and Synaptobrevin 2/Vesicle-Associated Membrane Protein-2 are associated with the progression of bladder cancer Genet. Mol. Biol.
Raja,Sadaf Azad; Abbas,Seher; Shah,Syed Tahir Abbas; Tariq,Aamira; Bibi,Nazia; Yousuf,Arzu; Khawaja,Athar; Nawaz,Muhammad; Mehmood,Arshad; Khan,Muhammad Jadoon; Hussain,Alamdar.
Abstract Gene expression is tightly regulated in time and space through a multitude of factors consisting of signaling molecules. Soluble N-ethylmaleimide-sensitive-factor attachment protein receptors (SNARE) are membrane proteins responsible for the intercellular trafficking of signals through endocytosis and exocytosis of vesicles. Altered expression of SNARE proteins in cellular communication is the major hallmark of cancer phenotypes as indicated in recent studies. SNAREs play an important role in maintaining cell growth and epithelial membrane permeability of the bladder and are not only involved in cancer progression but also metastatic cell invasion through SNARE-mediated trafficking. Synaptobrevin2/Vesicle associated membrane protein-2 (v-SNARE)...
Tipo: Info:eu-repo/semantics/article Palavras-chave: SNARE; Bladder cancer; Vesicle fusion; Gene expression.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019000100040
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Heterologous Expression of Syntaxin 6 in Saccharomyces cerevisiae Biol. Res.
GÖTTE,MARTIN; STADTBÄUMER,ANDREA.
The molecular mechanisms of vesicular protein transport in eukaryotic cells are highly conserved. Members of the syntaxin family play a pivotal role in the membrane fusion process. We have expressed rat syntaxin 6 and its cytoplasmic domain in wild-type and pep12 mutant strains of Saccharomyces cerevisiae to elucidate the role of the syntaxin 6-dependent vesicular trafficking step in yeast. Immunofluorescence microscopy revealed a punctate, Golgi-like staining pattern for syntaxin 6, which only partially overlapped with Pep12p in wild-type yeast cells. In contrast to Pep12p, syntaxin 6 was not mislocalized to the vacuole upon expression from 2 micron vectors, which might be attributed to conserved sorting and retention signals. Syntaxin 6 was not capable...
Tipo: Journal article Palavras-chave: Vesicular transport; SNARE; Syntaxin; Endosomal trafficking; Vacuole protein sorting; PEP12.
Ano: 2002 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000300009
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