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Anticoagulant and factor Xa-like activities of Tityus discrepans scorpion venom Acta Toxicol. Argent.
Brazón,Josmary; Guerrero,Belsy; Suze,D; Sevcik, Carlos,Gina; Arocha-Piñango,Carmen L.
Tityus discrepans venom (TdV) produces a variety of haemostatic manifestations including alveoli fbrin deposition and/ or prothrombin and partial thromboplastin time (PT, PTT) alterations in mammals. In vitro studies have demonstrated that TdV contains tissue plasminogen activator-like (t-PA), fbrinolytic and plasmin inhibitory compounds and produces platelets activation through GPVI and a novel Src-dependent signalling pathway. The aim of this study is to describe the initial characterization of procoagulant and anticoagulant components from TdV. This venom was fractionated by exclusion molecular chromatography on a Sephadex G-50 column. The eluted material was collected as fve fractions called S1 to S5. These fractions and the whole venom were used to...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Scorpion; Coagulation; Fibrinogen; Factor Xa.
Ano: 2013 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1851-37432013000100003
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Hematological and biochemical profiles of rats submitted to experimental poisoning with Tityus serrulatus venom Arq. Bras. Med. Vet. Zootec.
Pinto,M.C.L.; Melo,M.M.; Costa,M.E.R.; Labarrere,C.R..
The hematological and biochemical profiles of newly weaned rats submitted to experimental poisoning with T. serrulatus venom were evaluated. Fifteen recently weaned male Wistar rats (mean weight 130g) were distributed into three equal groups (n = 5). Animals in the control group (group A) received a subcutaneous injection of 400μL of ultra-pure water, while those in the experimental groups received, by identical route, 400μL of a solution containing 100μg (group B) or 450μg (group C) of scorpion venom dissolved in ultra-pure water. Red blood cells indexes, and differential leukocyte and total platelet counts were determined, together with levels of serum glucose, urea, creatinine, lactic dehydrogenase, aspartate aminotransferase, amylase, insulin, and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Rat; Tityus serrulatus; Scorpion; Experimental envenoming; Hematology; Biochemestry.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352010000200015
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Histopathological changes in albino mouse testis induced by the administration of Tityus n. sp. venom J. Venom. Anim. Toxins
PENNA-VIDEAÚ,S.; CERMEÑO-VIVAS,J.; MORENO-MARVAL,M.; QUIROGA-NOTTI,M..
Scorpion envenoming is a public health concern in northeastern Venezuela. Specimens of the genus Tityus are responsible for most of these. In experimental animals, Tityus venom produces histopathological changes in the skeletal muscle and pancreas, but its toxicity to the reproductive system has not been studied. The aim of this work is to describe the histopathological changes in testis and epididymis of albino mice induced by the administration of Tityus n. sp. venom. Sub-lethal doses of venom (3.75 mg/g mouse) were administered intramuscularly (IM) daily for 4 days. On the fifth day, the animals were sacrificed and the testes and epididymes were quickly removed and processed for light microscopy. The venom induced alterations in spermatogenesis. Sertoli...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Testis; Sertoli cell; Epididymis; Scorpion; Venom; Mouse; Histopathology.
Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79302000000200003
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The scorpion families and their geographical distribution J. Venom. Anim. Toxins
LOURENÇO,W. R..
A synoptic table is proposed for the families and genera of scorpions currently regarded as valid. Because there is considerable disagreement about the classification of scorpions, many changes are to be expected in the future. The classification proposed here is followed by considerations regarding the geographical distribution of each family.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Scorpion; Families; Genera; Check-list; Classification; Geographical distribution.
Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79302001000100002
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The presence of pharmacological substances myoglobin and histamine in venoms J. Venom. Anim. Toxins
LIPPS,B. V.; KHAN,A. A..
It is well documented that several pharmacological substances are released within the victim's body after snakebite. These substances are also believed to be endogenously present in animals, specifically levels of myoglobin and histamine that are reported to rise after envenomation. However, there is no published data regarding the presence of these substances in venoms per se. This research reports the detection of myoglobin and histamine in snake, scorpion, honeybee, and toad venoms by immunological test. It is unlikely that the rise in levels of myoglobin and histamine is due to that added from the bite, since a single toxin devoid of such components is capable of elevating levels of these substances. Nonetheless, it is likely that the rise in levels of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Myoglobin; Histamine; Snake; Honeybee; Scorpion; Toad; Venom; Crotalus atrox; Crotalus polystictus; Naja kaouthia; Oxyuranus s. scutellatus; Actinopyga agassizi; Bufo arenarum; Androcetonus australis; Apis mellifera.
Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79302001000100004
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INSULIN ADMINISTRATION IN SEVERE SCORPION ENVENOMING J. Venom. Anim. Toxins
YUGANDHAR,B.; RADHA KRISHNA MURTHY,K.; SATTAR,S. A..
The efficacy of insulin-glucose infusion in reversing myocardial damage, haemodynamic changes, peripheral circulatory failure, and pulmonary oedema was evaluated in 25 victims of venomous scorpion stings from the Rayalaseema region in the south of India. Myocardial damage with peripheral circulatory failure was seen in all scorpion sting victims. Ten of these victims also had pulmonary oedema. All the patients received continuous infusion of regular crystalline insulin at the rate of 0.3 U/g of glucose and glucose at the rate of 0.1 g/kg/h with supplementary potassium as needed, inotropic agents, oxygen, as well as maintenance of fluid, electrolytes and acid-base balance. Insulin-glucose infusion was associated with reversal of cardiovascular and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Scorpion; Myocardial damage; Pulmonary oedema; Insulin-glucose infusion; Peripheral circulatory failure.
Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79301999000200007
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SCORPIONS, SCORPIONISM, LIFE HISTORY STRATEGIES AND PARTHENOGENESIS J. Venom. Anim. Toxins
LOURENÇO,W.R.; CUELLAR,O..
Recently public health problems resulting from scorpion stings have shown an alarming increase in various tropical and subtropical countries such as Brazil, Mexico, Tunisia and Morocco. In some regions of Brazil, particularly in the States of Minas Gerais, São Paulo, Bahia, Goiás and the Federal District, more than 6000 scorpion stings with over 100 deaths were reported during a three-year period. In this paper, we attempt to demostrate the effects of human activities on the environment and their consequences on the distribution of dangerous species of scorpions. This topic is discussed in relation to the evolutionary ecology, life history strategies and asexual reproduction of scorpions.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Scorpionism; Scorpion; Life history strategy; Parthenogenesis; Brazil.
Ano: 1995 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79301995000200002
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The description of Tityus caripitensis. A new venezuelan scorpion (scorpionida, buthidae) J. Venom. Anim. Toxins
QUIROGA,M.; DE SOUSA,L.; PARRILLA-ALVAREZ,P..
This paper describes a new species of scorpion of the Tityus genus, Tityus caripitensis (Scorpionida: Buthidae). This species can be found in Caripito, Bolívar municipality of Monagas State, Venezuela. The number of species of Tityus genus in Venezuela has increased to 37 with the inclusion of Tityus caripitensis. A diagnosis of the most significant morphological characteristics of both males and females of this new species, which has been causing serious envenomings in the Bolívar and Punceres municipalities, has been carried out.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Scorpion; Tityus; New species; Venezuela.
Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79302000000100007
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Individual variation in the protein profile of the venom of Mesobuthus gibbosus (Brullé, 1832, Scorpiones: Buthidae) from Turkey J. Venom. Anim. Toxins incl. Trop. Dis.
Ozkan,O; Ciftci,G.
Mesobuthus gibbosus (Brullé, 1832) scorpions were collected from the Mugla province in the Aegean region of Turkey and housed in individual boxes. After extraction, the venom composition was analyzed using gel electrophoresis (SDS-PAGE). Interestingly, all scorpion venom samples contained only one protein band (~68 kDa) in common. Two protein bands (30 and 98 kDa) were common in six venom samples and were absent in the other venoms. Furthermore, two different protein bands (28 and 45 kDa) were detected in seven venom samples. This study proposes possible variations in the composition of individual scorpion venom samples collected from the same geographic region, based on the electrophoretic profile. Additional studies will be necessary in order to assess...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Scorpion; Mesobuthus gibbosus; Venom; Protein; Turkey.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992010000300017
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Incidence and severity of scorpion stings in Algeria J. Venom. Anim. Toxins incl. Trop. Dis.
Laïd,Y; Boutekdjiret,L; Oudjehane,R; Laraba-Djebari,F; Hellal,H; Guerinik,M; Griene,L; Alamir,B; Merad,R; Chippaux,JP.
Scorpion stings are a public health problem in the Maghreb region. In Algeria, epidemiological data were collected over the past twenty years by the Algerian health authorities. This study is an analysis of morbidity and mortality data collected from 2001 to 2010. Annual incidence and mortality due to scorpion envenoming were 152 ± 3.6 stings and 0.236 ± 0.041 deaths per 100,000 people (95% CI), respectively. The risk of being stung by a scorpion was dramatically higher in southern areas and central highlands due to environmental conditions. Incidence of envenoming was especially higher in the adult population, and among young males. In contrast, mortality was significantly higher among children under 15 years, particularly ages 1-4. Upper limbs were more...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Scorpion; Stings; Envenoming; Deaths; Epidemiology; Management; Algeria.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992012000400008
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Euscorpius (Scorpiones, Euscorpiidae): three cases of stings in northwestern Italy J. Venom. Anim. Toxins incl. Trop. Dis.
Dutto,M; Dutto,L; Scaglione,N; Bertero,M.
In the period between June 2008 and August 2009, three cases of stings of Euscorpius scorpions indigenous to Italy were treated at two different emergency departments (ED) in hospitals of the Piedmont region, northwest Italy: Santa Croce e Carle General Hospital in Cuneo, and Santissima Annunziata Hospital in Savigliano. Scorpion stings in Italy are rare and not well documented in the literature; this situation may raise doubts among medical personnel as to how such lesions are best treated. Analysis of the incidents confirms that the venom of Euscorpius do not provokes systemic poisoning in humans and in these cases even dermatological reactions were not significant.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Euscorpius; Scorpion; Sting; Scorpionism; Venom; Poisoning; Italy.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992010000400018
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Effects of Androctonus crassicauda (Olivier, 1807) (scorpiones: buthidae) venom on rats: correlation among acetylcholinesterase activities and electrolytes levels J. Venom. Anim. Toxins incl. Trop. Dis.
Ozkan,O.; Adiguzel,S.; Kar,S.; Kurt,M.; Yakistiran,S.; Cesaretli,Y.; Orman,M.; Karaer,Z..
Scorpions can be considered living fossils because they have changed so little during the last 400 million years. They are venomous arthropods of the Arachnida class and regarded as relatives of spiders, ticks and mites. The aim of the present study was to evaluate the toxicity of Androctonus crassicauda (Olivier, 1807) venom and its effects on the acetylcholinesterase (AchE) activity and on electrolytes levels in rats. Animals were divided into seven groups of five rats each. Test groups received 250µg/kg of venom solution while control group was treated with 200µl of physiological saline solution (PSS). Blood samples were collected from the animals on the 1st, 2nd 4th, 8th, 12th, and 24th hours after subcutaneous injection of venom. Animals were...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Scorpion; Androctonus crassicauda; Venom; Acetylcholinesterase; Electrolytes.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992007000100005
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Risk factors for scorpion stings in the beni mellal province of morocco J. Venom. Anim. Toxins incl. Trop. Dis.
Charrab,N; El Oufir,R; Soulaymani,A; Semlali,I; Mokhtari,A; Soulaymani,R.
Scorpion stings comprise a serious problem throughout the globe, especially in regions where they are more frequent. In Morocco, Beni Mellal is one of the provinces most affected by this burden. This study aimed to trace the epidemiological profile of scorpion stings in Beni Mellal in order to improve patient care and prevent both morbidity and mortality. Our work is a retrospective study of scorpion stings based on medical charts of Beni Mellal. From 2002 to 2007, 8,340 cases were registered in this province with an average incidence of 1.36‰. The stings were more frequent in summer months, particularly July and August, and between 6 p.m. and 6 a.m. (59.8%). The average age of victims was 26.54 ± 18.42 years. Children were affected in 30.3% of the cases....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Epidemiology; Scorpion; Register; Beni Mellal; Morocco.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992009000400009
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Risk factors caused by scorpion stings and envenomations in the province of Kelâa Des Sraghna (Morocco) J. Venom. Anim. Toxins incl. Trop. Dis.
Hmimou,R; Soulaymani,A; Mokhtari,A; Arfaoui,A; Eloufir,G; Semlali,I; Soulaymani Bencheikh,R.
The present study aims to elucidate the risk factors involved in deaths caused by scorpion envenomation. A retrospective study was carried out in the province of Kelâa des Sraghna from 2003 to 2004. The hospital charts of scorpion envenomation cases treated in the Essalama Hospital in Kelâa des Sraghna were exhaustively analyzed. Our study contains 31 cases of death among 470 hospitalization cases. Most stings had occurred during the hot period peaking in July and August (54.6%). Moreover, the scorpion stings occurred at night in 60.1% of the cases, between 6:00 pm and 6:00 am. In addition, all age groups were affected by envenomation, with a higher frequency in children aged less than 15 years (68.3%). The envenomation rate (class II + class III) was...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Scorpion; Morocco; Epidemiology; Kelâa province of Sraghna.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992008000400006
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Clinical and cardiovascular alterations produced by scorpion envenomation in dogs J. Venom. Anim. Toxins incl. Trop. Dis.
Cordeiro,F. F.; Sakate,M.; Fernandes,V.; Cuyumjian,P. R..
Scorpionism is a common problem that occurs in tropical and subtropical countries and assumes great medical-sanitary importance due to its fatal effect on sensitive individuals, being able to lead children and aged people to death. The envenomation lethal potential is responsible for the serious cardiopulmonary alterations the scorpion toxin produces in its victims. The present research evaluated the effects of Tityus serrulatus venom on dogs, using two distinct doses: a dose that simulates natural envenomation (0.4 mg/total dose), and an experimental dose (0.25 mg/kg). General clinical signs were observed at different moments after envenomation, and specific data related to the cardiopulmonary system were evaluated by systemic arterial pressure...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Scorpion; Dogs; Cardiopulmonary alterations; Tityus serrulatus.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992006000100003
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Scorpion incidents, misidentification cases and possible implications for the final interpretation of results J. Venom. Anim. Toxins incl. Trop. Dis.
Lourenço,Wilson R..
Abstract The aim of this contribution is to bring general information on the classification and in particular on the specific identification of scorpion species dangerous to humans. Several generic groups are taken into consideration, but the Neotropical genus Tityus C. L. Koch, 1836 is used as a major example. The content of this paper is mostly addressed to non-specialists whose research embraces scorpions in several fields such as venom toxins and public health. Although efforts have been made in the last 20 years to create better links between ‘true scorpion experts’ and non-specialists who use scorpions in their research, such exchanges had never led to a consensus among those different branches of biological and medical research. Consequently, many...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Scorpion; Dangerous species; Misidentification; Biased results; Buthidae; Tityus.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100202
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Histology and histochemistry of the venom apparatus of the black scorpion Androctonus crassicauda (Olivier, 1807) (Scorpiones: Buthidae) J. Venom. Anim. Toxins incl. Trop. Dis.
Jarrar,BM; Al-Rowaily,MA.
The venom apparatus of the black scorpion Androctonus crassicauda has been characterized histologically and histochemically in the present study. The results showed that this apparatus consists of paired venom glands, each of which initially presents its own canal and posteriorily both fuse into a single common one. Each gland is covered by a sheath of striated muscle and is lined with extensively folded secretory epithelium (formed of non-secretory and secretory venom-producing cells). The outcomes also revealed that the venom-producing cells of both glands produce neutral mucosubstances, sialomucins, sulfomucins and proteins, but are devoid of glycogen. Cysteine, tyrosine, tryptophan and arginine were also detected along with activities of acid and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Androctonus; Scorpion; Venom apparatus; Histochemistry; Phosphatases; Esterases; Peptidases.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992008000300010
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Divergences between the Brazilian national information systems for recording deaths from venomous animals J. Venom. Anim. Toxins incl. Trop. Dis.
Bochner,Rosany; Souza,Claudio Mauricio Vieira de.
Abstract Background: This paper aims to highlight and analyze discrepancies in reporting of deaths due to venomous animals in Brazil, from 2001 to 2015, between two national information systems: The Notifiable Diseases Information System (Sistema de Informação de Agravos de Notificação - SINAN) and the Mortality Information System (Sistema de Informações sobre Mortalidade - SIM). Methods: Descriptive and comparative study of the SINAN and SIM information systems, was conducted via the following steps: collecting the death notices from SINAN and SIM; constructing tables and comparative graphics; and, only in scorpion sting fatalities, analyzing the distribution of deaths by age group as described in the specialized literature. Results: While SINAN...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Information system; Death; SINAN; SIM; Snake; Spider; Scorpion; Bee.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992019000100313
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Determination of potency and paraspecific effects of Androctonus crassicauda (Olivier, 1807) antivenom against Mesobuthus gibbosus (Brullé, 1832) venom (Scorpiones: Buthidae) J. Venom. Anim. Toxins incl. Trop. Dis.
Ozkan,O.; Adiguzel,S.; Kar,S.; Yakistiran,S.; Cesaretli,Y.; Karaer,K. Z..
Scorpion envenomation remains a real health problem in many countries. In scorpionism cases, it is often recommended that patients be treated with species-specific antivenom. Androctonus crassicauda venom has been used as antigen for antivenom production in Turkey, where this antivenom, called Turkish antivenom, has also been effective in the treatment of envenomation caused by species other than A. crassicauda. The present study aimed at determining the paraspecific effects and potency of the Turkish antivenom against Mesobuthus gibbosus (Brullé, 1832) venom. To assess the venom toxicity and the antivenom efficacy, we determined the Minimum Lethal Dose (MLD) and the Minimum Effective Dose (MED) instead of LD50 and ED50, respectively. Androctonus...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Scorpion; Antivenom; Androctonus crassicauda; Mesobuthus gibbosus; Paraspecific activity.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992007000200008
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Predictive determinants of scorpion stings in a tropical zone of south Iran: use of mixed seasonal autoregressive moving average model J. Venom. Anim. Toxins incl. Trop. Dis.
Ebrahimi,Vahid; Hamdami,Esmael; Moemenbellah-Fard,Mohammad Djaefar; Jahromi,Shahrokh Ezzatzadegan.
Abstract Background: More than 1.2 million scorpion stings occur annually worldwide, particularly in tropical regions. In the absence of proper medical care, mortality due to venomous scorpion stings is an important public health issue. The aim of the present study is to explore the temporal trend of scorpionism with time series models and determine the effective factors on this event using regression models. Methods: A retrospective cross sectional study was conducted on 853 scorpion stung patients. They were referred to Haji-Abad Hospital of Hormozgan University of Medical Sciences (HUMS), south Iran, from May 2012 to July 2016. A linear model to describe and predict the monthly trend of scorpion sting cases is fit with autoregressive moving average...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Climate; Mixed seasonal ARMA; Regression analysis; Scorpion; Scorpion stings; Time series; Iran.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992017000100315
Registros recuperados: 38
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