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	Provedor de dados BJMBR (1) J. Venom. Anim. Toxins incl. Trop. Dis. (1) Autor Barreto,SA (1) Cunha-Melo,J.R. (1) Dorce,VAC (1) Florio,JC (1) Garbacio,V.L. (1) Lebrun,I (1) Lourenço,GA (1) Nencioni,ALA (1) Santos,A.A. (1) Secaf,M. (1) Troncon,L.E.A. (1) Verceze,A.V. (1) Mais... Palavra-chave Scorpion toxin (2) Gastric emptying (1) Gastrointestinal motility (1) Hippocampus (1) Intestinal transit (1) Microdialysis (1) Neurodegeneration (1) Neurotransmitters (1) Riluzole (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2009 (1) 2000 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Neurotransmitter evaluation in the hippocampus of rats after intracerebral injection of TsTX scorpion toxin J. Venom. Anim. Toxins incl. Trop. Dis. Nencioni,ALA; Barreto,SA; Lebrun,I; Florio,JC; Lourenço,GA; Dorce,VAC. TsTX is an α-type sodium channel toxin that stimulates the discharge of neurotransmitters from neurons. In the present study we investigated which neurotransmitters are released in the hippocampus after TsTX injection and if they are responsible for electrographic or histopathological effects. Microdialysis revealed that the toxin increased glutamate extracellular levels in the hippocampus; however, levels of gamma-aminobutyric acid (GABA), glycine, 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA) and 3,4-dihydroxyphenylacetic acid (DOPAC) were not significantly altered. Neurodegeneration in pyramidal cells of hippocampus and electroencephalographic alterations caused by the toxin were blocked by pretreatment with riluzole, a glutamate release... Tipo: Info:eu-repo/semantics/article Palavras-chave: Scorpion toxin; Microdialysis; Hippocampus; Neurotransmitters; Neurodegeneration; Riluzole. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992009000200007 Inhibition of gastric emptying and intestinal transit in anesthetized rats by a Tityus serrulatus scorpion toxin BJMBR Troncon,L.E.A.; Santos,A.A.; Garbacio,V.L.; Secaf,M.; Verceze,A.V.; Cunha-Melo,J.R.. The effects of a fraction (T1) of Tityus serrulatus scorpion venom prepared by gel filtration on gastric emptying and small intestinal transit were investigated in male Wistar rats. Fasted animals were anesthetized with urethane, submitted to tracheal intubation and right jugular vein cannulation. Scorpion toxin (250 µg/kg) or saline was injected iv and 1 h later a bolus of saline (1.0 ml/100 g) labeled with 99m technetium-phytate (10 MBq) was administered by gavage. After 15 min, animals were sacrificed and the radioactivity remaining in the stomach was determined. Intestinal transit was evaluated by instillation of a technetium-labeled saline bolus (1.0 ml) through a cannula previously implanted in the duodenum. After 60 min, the progression of the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Scorpion toxin; Gastric emptying; Intestinal transit; Gastrointestinal motility. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000900010 Registros recuperados: 2 Primeira ... 1 ... Última

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