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	Provedor de dados BJPS (2) Autor Ansari,Khalid Akhter (1) Anwar,Shoeb (1) Butani,Shital (1) Laddha,Pankaj (1) Pagar,Kunal Pratap (1) Suthar,Vrunda (1) Vavia,Pradeep Ratilal (1) Mais... Palavra-chave Self-microemulsifying drug delivery system/development (2) Biopharmaceutical Classification System (1) Chronotherapeutics/hypertension treatment (1) Domperidone/self-microemulsifying delivery (1) Drugs/controlled release (1) Ethyl cellulose/drugs coated (1) Felodipine/chronotherapeutic application (1) Felodipine/self-microemulsifying delivery (1) Hypertension/treatment (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2014 (2) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Design and optimization of self-microemulsifying drug delivery system (SMEDDS) of felodipine for chronotherapeutic application BJPS Ansari,Khalid Akhter; Pagar,Kunal Pratap; Anwar,Shoeb; Vavia,Pradeep Ratilal. The objective of this research work was to design, develop and optimize the self micro-emulsifying drug delivery system (SMEDDS) of Felodipine (FL) filled in hard gelatine capsule coated with polymer in order to achieve rapid drug release after a desired time lag in the management of hypertension. Microemulsion is composed of a FL, Lauroglycol FCC, Transcutol P and Cremophor EL. The optimum surfactant to co-surfactant ratio was found to be 2:1. The resultant microemulsions have a particle size in the range of 65-85 nm and zeta potential value of -13.71 mV. FL release was adequately adjusted by using pH independent polymer i.e. ethyl cellulose along with dibutyl phthalate as plasticizer. Influence of formulation variables like viscosity of polymer, type of... Tipo: Info:eu-repo/semantics/article Palavras-chave: Felodipine/self-microemulsifying delivery; Felodipine/chronotherapeutic application; Self-microemulsifying drug delivery system/development; Drugs/controlled release; Ethyl cellulose/drugs coated; Hypertension/treatment; Chronotherapeutics/hypertension treatment. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000100021 Development and optimization of self microemulsifying drug delivery of domperidone BJPS Laddha,Pankaj; Suthar,Vrunda; Butani,Shital. The present investigation is aimed to develop self-microemulsifying drug delivery system (SMEDDS) to improve the in vitro dissolution of a BCS (Biopharmaceutical Classification System) class II anti emetic agent, domperidone. Solubility study was performed to identify the ingredients showing highest solubility of domperidone. The ternary phase diagrams were plotted for selected components to identify the area of microemulsion existence. D-optimal mixture experimental design was applied to optimize a liquid SMEDDS using formulation variables; the oil phase X1 (Oleic acid), the surfactant X2 (Labrasol) and the co-surfactant X3 (Transcutol HP). The liquid SMEDDS were evaluated for droplet size, emulsification time, % transmittance and drug release. Stability... Tipo: Info:eu-repo/semantics/article Palavras-chave: Domperidone/self-microemulsifying delivery; Self-microemulsifying drug delivery system/development; Biopharmaceutical Classification System. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000100009 Registros recuperados: 2 Primeira ... 1 ... Última

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