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	Provedor de dados BJMBR (2) Autor Cai,D.A. (1) Chun,Zhang (1) Hai,Wang (1) Ma,B.J. (1) Ping,Xu (1) Wang,Y.F. (1) Wu,M. (1) Yin,B.B. (1) Zhi-wen,Yang (1) Mais... Palavra-chave Severe acute pancreatitis (2) Caspase recruitment domain-containing protein 9 (1) Growth hormone (1) High-mobility group box 1 (1) Inflammatory response (1) Pioglitazone (1) Somatostatin (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2018 (1) 2014 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Role of high mobility group box-1 and protection of growth hormone and somatostatin in severe acute pancreatitis BJMBR Wang,Y.F.; Wu,M.; Ma,B.J.; Cai,D.A.; Yin,B.B.. In this study, we investigated the potential role of high-mobility group box 1 (HMGB1) in severe acute pancreatitis (SAP) and the effects of growth hormone (G) and somatostatin (S) in SAP rats. The rats were randomly divided into 6 groups of 20 each: sham-operated, SAP, SAP+saline, SAP+G, SAP+S and SAP+G+S. Ileum and pancreas tissues of rats in each group were evaluated histologically. HMGB1 mRNA expression was measured by reverse transcription-PCR. Levels of circulating TNF-α, IL-1, IL-6, and endotoxin were also measured. In the SAP group, interstitial congestion and edema, inflammatory cell infiltration, and interstitial hemorrhage occurred in ileum and pancreas tissues. The levels of HMGB1, TNF-α, IL-1, IL-6 and endotoxin were significantly up-regulated... Tipo: Info:eu-repo/semantics/article Palavras-chave: Severe acute pancreatitis; High-mobility group box 1; Growth hormone; Somatostatin; Inflammatory response. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014001201075 [RETRACTED ARTICLE] Therapeutic effect and potential mechanism of pioglitazone in rats with severe acute pancreatitis BJMBR Hai,Wang; Ping,Xu; Zhi-wen,Yang; Chun,Zhang. Caspase recruitment domain-containing protein 9 (Card9) is located upstream of the nuclear factor kappa B (NF-κB) and p38 mitogen-activated protein kinase (MAPK) inflammatory pathways. This study investigated the therapeutic effect and potential mechanism of pioglitazone in rats with severe acute pancreatitis (SAP). SAP was induced by a retrograde infusion of 5.0% sodium taurocholate into the biliopancreatic duct of Sprague Dawley rats (n=54), which were then treated with pioglitazone. Blood and pancreatic tissues were harvested at 3, 6, and 12 h after SAP induction. Pancreatic pathological damage was evaluated by hematoxylin and eosin staining. Serum amylase, serum pro-inflammatory cytokines, and pancreatic myeloperoxidase (MPO) activities were determined... Tipo: Info:eu-repo/semantics/article Palavras-chave: Caspase recruitment domain-containing protein 9; Pioglitazone; Severe acute pancreatitis. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000200612 Registros recuperados: 2 Primeira ... 1 ... Última

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