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| PRADEEP,KANNAMPALLI; RAJ MOHAN,CHANDRASEKARAN VICTOR; GOBIANAND,KUPANNAN; KARTHIKEYAN,SIVANESAN. |
| Diethylnitrosamine (DEN), found in many commonly consumed foods, is widely reported to induce cancer in animals and humans. The aim of the present study was to investigate the hepatoprotective and antioxidant activities of the leaf extract of the medicinal plant Cassia fistula Linn. against diethylnitrosamine induced liver injury in ethanol pretreated rats. Albino Wistar rats, pretreated with ethanol for 15 days, were administered a single dose of DEN. Thirty days after DEN administration, hepatotocellular damage was observed histologically, along with elevated levels of serum AST, ALT, ALP, LDH, γ-GT and bilirubin and a simultaneous fall in the levels of the marker enzymes in the liver tissue. Liver oxidative stress was confirmed by elevated... |
| Tipo: Journal article |
Palavras-chave: Antioxidants; Cassia fistula; Diethylnitrosamine; Hepatoprotective; Lipid peroxidation; Silymarin. |
| Ano: 2010 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000100013 |
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| Al-Rasheed,Nouf; Faddah,Laila; Sharaf,Iman A; Mohamed,Azza M; Al-Rasheed,Nawal; Abdelbaky,Nayira. |
| ABSTRACT The aim of this study was to investigate the effective role of silymarin either alone or in a combination with vitamin E and/or curcumin against the toxic impact of carbon tetrachloride (CCl4) induced liver injury The results revealed that administration of silymarin alone or in a combination with vitamin E and/or curcumin for 21 consecutive days, 24 h after CCl4 injection to rats, markedly ameliorated DNA damaged and apoptosis markers in rat livers, proinflammatory markers including tumor necrosis factor- α (TNF- α) and C-reactive protein (CRP ) in rat livers as well as interleukin 6 (IL-6), interferon gamma (IFN-γ) and vascular endothelial growth factor (VEGF) in rat sera. These treatments also could ameliorated the alteration in cytochrome P450... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Silymarin; Vitamin E; Curcumin; Carbon Tetrachloride. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132015000600833 |
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| Yousaf,Abid Mehmood; Malik,Usman Rashid; Shahzad,Yasser; Hussain,Talib; Khan,Ikram Ullah; Din,Fakhar Ud; Mahmood,Tariq; Ahsan,Hafiz Muhammad; Syed,Ahmed Shah; Akram,Muhammad Rouf. |
| Abstract The aim of the present research was to develop a silymarin-laden PVP-nanocontainer providing ameliorated aqueous solubility and dissolution of the drug. Several silymarin-laden formulations were formed with varying quantities of PVP and SDS via the solvent evaporation method using the electrospraying technique. The influence of the hydrophilic carriers on solubility and dissolution was explored. The solid-state characterization was carried out by particle-size analysis, PXRD, DSC, FTIR and SEM. All of the formulations demonstrated better solubility and dissolution than did silymarin plain powder. Both the SDS and PVP had positive effects on solubility and dissolution of silymarin in the aqueous media. An increased solubility was attained as the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Silymarin; Electrospraying; PVP-nanocontainers; Aqueous solubility; Dissolution. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132019000100612 |
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