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| Eger,Guilherme A.; Ferreira,Vinícius V.; Batista,Camila R.; Bonde,Henrique; Lima,Daniela D. de; Wyse,Angela T.S.; Cruz,Júlia N. da; Rodrigues,André F.; Magro,Débora D. Dal; Cruz,José G.P. da. |
| The present study aims to directly investigate the behavioral and antioxidant effects of simvastatin in a model of bipolar mania induced by lisdexamfetamine dimesylate. Wistar rats were treated for 30 days with simvastatin. On the 24th day after the start of treatment, each rat was administered lisdexamfetamine dimesylate for 7 days. The results suggest that simvastatin combined with lisdexamfetamine dimesylate induced a significant increased locomotion and lisdexamfetamine dimesylate administration causes an oxidative imbalance determined by an increment in lipid peroxidation, protein oxidation and alterations in the activities of antioxidant enzymes in brain areas; moreover, in the presence of simvastatin, most of these effects were prevented. These... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Amphetamine; Lisdexamfetamine dimesylate; Oxidative stress; Simvastatin. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000100335 |
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| Brilhante,Raimunda Sâmia Nogueira; Caetano,Erica Pacheco; Oliveira,Jonathas Sales de; Castelo-Branco,Débora de Souza Collares Maia; Souza,Elizabeth Ribeiro Yokobatake; Alencar,Lucas Pereira de; Cordeiro,Rossana de Aguiar; Bandeira,Tereza de Jesus Pinheiro Gomes; Sidrim,José Júlio Costa; Rocha,Marcos Fábio Gadelha. |
| ABSTRACTThe antifungal activity of some statins against different fungal species has been reported. Thus, at the first moment, the in vitro antifungal activity of simvastatin, atorvastatin and pravastatin was tested againstCandida spp. and Cryptococcus spp. Then, in a second approach, considering that the best results were obtained for simvastatin, this drug was evaluated in combination with antifungal drugs against planktonic growth and tested against biofilms ofCandida spp. and Cryptococcus spp. Drug susceptibility testing was performed using the microdilution broth method, as described by the Clinical and Laboratory Standards Institute. The interaction between simvastatin and antifungals against planktonic cells was analyzed by calculating the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Candida; Cryptococcus; Simvastatin; Antifungal activity; Biofilm. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000500459 |
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| Santos,L.; Davel,A.P.; Almeida,T.I.R.; Almeida,M.R.; Soares,E.A.; Fernandes,G.J.M.; Magalhães,S.F.; Barauna,V.G.; Garcia,J.A.D.. |
| Functional food intake has been highlighted as a strategy for the prevention of cardiovascular diseases by reducing risk factors. In this study, we compared the effects of oral treatment with soy milk and simvastatin on dyslipidemia, left ventricle remodeling and atherosclerotic lesion of LDL receptor knockout mice (LDLr-/-) fed a hyperlipidic diet. Forty 3-month old male LDLr-/- mice were distributed into four groups: control group (C), in which animals received standard diet; HL group, in which animals were fed a hyperlipidic diet; HL+SM or HL+S groups, in which animals were submitted to a hyperlipidic diet plus soy milk or simvastatin, respectively. After 60 days, both soy milk and simvastatin treatment prevented dyslipidemia, atherosclerotic lesion... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Soy milk Dyslipidemia Oxidative stress Inflammation Atherosclerosis; Simvastatin. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000300701 |
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| Bulcão,C.; Giuffrida,F.M.A.; Ribeiro-Filho,F.F.; Ferreira,S.R.G.. |
| In addition to lipid-lowering and cardiovascular protective actions, statins may have beneficial effects on insulin sensitivity. The objective of the present study was to evaluate the effect of simvastatin therapy on insulin resistance and on leptin, adiponectin, and C-reactive protein (CRP) levels, as compared to metformin, in overweight pre-diabetic subjects. Forty-one subjects with BMI >25 kg/m² and impaired fasting glucose or impaired glucose tolerance were randomized to take simvastatin, 20 mg/day (N = 20) or metformin, 1.7 g/day (N = 21) for 16 weeks. Blood samples for the determination of metabolic, hormonal, and inflammatory parameters were obtained at baseline and after each treatment. After metformin therapy, significant reductions in mean BMI... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Simvastatin; Metformin; Insulin resistance; Leptin; Adiponectin. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000200009 |
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| Kolovou,Genovefa; Kolovou,Vana; Ragia,Georgia; Mihas,Constantinos; Diakoumakou,Olga; Vasiliadis,Ioannis; Mavrogeni,Sophie; Vartela,Vassiliki; Manolopoulos,Vangelis G. |
| In this work, we examined the impact of polymorphism in the cytochrome P450 (CYP) 3A5 gene, CYP3A5*1 (6986A > G, rs 776746), on the reduction in the lipid levels caused by simvastatin and atorvastatin. We studied 350 hyperlipidemic patients who received 10-40 mg of atorvastatin (n = 175) or simvastatin (n = 175) daily. Genotyping for CYP3A5 was done by PCR-RFLP analysis. Differences in the lipid profile before and after treatment were expressed as the % difference. The frequency of CYP3A5 polymorphism was 13.4% for heterozygotes and 86.6% for homozygotes. Comparison of the responses to same dose of each drug showed that the highest % difference was associated with total cholesterol (TC) in subjects receiving atorvastatin 40 mg compared with simvastatin... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Atorvastatin; Cholesterol; CYP3A5 gene polymorphism; Simvastatin. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572015000200129 |
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| Accioly,Marilita Falângola; Souza,Dorotéia Rossi Silva; Padulla,Susimary Aparecida Trevizan; Camargo Filho,José Carlos Silva; do Carmo,Edna Maria; Martins,Alex Tadeu; Brandão,Antônio Carlos; Azoubel,Reinaldo. |
| The present study was carried out to evaluate the effect of statins associated with physical exercise (PE) in liver cells in dyslipidemic rats through cariometry. The animals were divided into six groups: animals subjected to a hypercholesterolemic diet (HD), simvastatin, with (G1) and without (G2) physical exercise (PE); HD submitted (G3) or not (G4) to PE, and commercial food diet (F) with (G5) and without (G6) PE. Histological analysis of the liver was performed by staining the slides with hematoxylin and eosin. The cariometric study included measuring the major and minor diameters of the hepatocytes nuclei. The Shapiro-Wilk test was also performed. To determine the differences among the groups, the Kruskal-Wallis Test with Dunn's post-test were... |
| Tipo: Journal article |
Palavras-chave: Simvastatin; Exercise; Diet; Cariometry. |
| Ano: 2013 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022013000400026 |
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