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	Provedor de dados BJMBR (1) Autor Pinheiro,N.A. (1) Villa,L.L. (1) Palavra-chave DNA sequencing (1) HPV (1) PCR (1) SSCP (1) Single-stranded conformation polymorphism (1) Suppressor gene (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Ano 2001 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Low frequency of p53 mutations in cervical carcinomas among Brazilian women BJMBR Pinheiro,N.A.; Villa,L.L.. Human papillomavirus (HPV) infections of the high-risk types are strongly linked to the development of cervical carcinoma. The HPV oncoproteins E6 and E7 are thought to play a crucial role in this process through their interactions with the p53 protein and the retinoblastoma susceptibility gene product pRb, respectively. E6 binds to p53 protein promoting its degradation. This is considered to contribute to the oncogenesis of HPV-associated anogenital cancer. On the other hand, in HPV-negative cervical carcinoma, p53 mutations are thought to have a role in the transformation process. A total of 122 HPV-positive cervical carcinoma tissue samples were evaluated for the presence of mutations in exons 5-8 of the p53 gene by single-stranded conformation... Tipo: Info:eu-repo/semantics/article Palavras-chave: Single-stranded conformation polymorphism; SSCP; Suppressor gene; HPV; PCR; DNA sequencing. Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000600005 Registros recuperados: 1 Primeira ... 1 ... Última

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