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	Provedor de dados Biol. Res. (1) BJMBR (1) Autor Chen,Xiao (1) Gao,Ying-fang (1) Li,Yuehua (1) Wang,Dan (1) Wei,Xiaoer (1) Zhang,Guo-hua (1) Zhang,Xia (1) Zhang,Xue-ling (1) Mais... Palavra-chave Sirt1 (2) Artesunate (1) Breast cancer (1) CD4+ T cells (1) MiR-142 (1) MiR-22 (1) Ovarian cancer (1) Radiosensitivity (1) Th1 cells (1) Tumorigenesis (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Journal article (1) Ano 2019 (1) 2017 (1) País Brazil (1) Chile (1) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última miR-22 suppresses tumorigenesis and improves radiosensitivity of breast cancer cells by targeting Sirt1 Biol. Res. Zhang,Xia; Li,Yuehua; Wang,Dan; Wei,Xiaoer. Abstract Background miR-22 has been shown to be frequently downregulated and act as a tumor suppressor in multiple cancers including breast cancers. However, the role of miR-22 in regulating the radioresistance of breast cancer cells, as well as its underlying mechanism is still not well understood. Methods The expressions of miR-22 and sirt1 at mRNA and protein levels were examined by qRT-PCR and Western Blot. The effects of miR-22 overexpression and sirt1 knockdown on cell viability, apoptosis, radiosensitivity, γ-H2AX foci formation were evaluated by CCK-8 assay, flow cytometry, colony formation assay, and γ-H2AX foci formation assay, respectively. Luciferase reporter assay and qRT-PCR analysis were performed to confirm the... Tipo: Journal article Palavras-chave: MiR-22; Tumorigenesis; Radiosensitivity; Breast cancer; Sirt1. Ano: 2017 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602017000100220 Artesunate promotes Th1 differentiation from CD4+ T cells to enhance cell apoptosis in ovarian cancer via miR-142 BJMBR Chen,Xiao; Zhang,Xue-ling; Zhang,Guo-hua; Gao,Ying-fang. The aim of this study was to evaluate the influence of artesunate on Th1 differentiation and its anti-tumor effect on ovarian cancer. A Murine ovarian cancer model was established by ID8 cells transplantation. The expression of miR-142 and Sirt1 proteins in peripheral CD4+ T cells were quantified with qRT-PCR and western blot, respectively. Peripheral CD4+ T cells were induced for Th1 differentiation. The percentages of apoptosis of Th1/CD4+ T cells and ovarian cancer cells were analyzed by flow cytometry. The IFN-γ level was examined through enzyme-linked immunosorbent assay. Artesunate promoted miR-142 expression in peripheral CD4+ T cells and Th1 differentiation from CD4+ T cells. Artesunate promoted cell apoptosis of ovarian cancer cells by inducing... Tipo: Info:eu-repo/semantics/article Palavras-chave: Artesunate; Ovarian cancer; CD4+ T cells; Th1 cells; MiR-142; Sirt1. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000500606 Registros recuperados: 2 Primeira ... 1 ... Última

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