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	Provedor de dados ArchiMer (1) BABT (1) Autor Amaral,Vanessa Cristiane de Santana (1) Cahu, Chantal (1) Gisbert, Enric (1) Nunes Junior,Guilhermino Pereira (1) Quazuguel, Patrick (1) Villeneuve, Laure (1) Zambonino, Jose-luis (1) Mais... Palavra-chave Skeletal malformations (2) Dicentrarchus labrax larvae (1) Embryotoxicity (1) Fluconazole (1) Ketoconazole (1) Maternal toxicity (1) Neutral lipids (1) Phospholipids (1) Retinoic acid receptors (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Text (1) Ano 2008 (1) 2005 (1) País Brazil (1) France (1) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Effect of nature of dietary lipids on European sea bass morphogenesis: implication of retinoid receptors ArchiMer Villeneuve, Laure; Gisbert, Enric; Zambonino, Jose-luis; Quazuguel, Patrick; Cahu, Chantal. The effect of the nature and form of supply of dietary lipids on larval development was investigated in European sea bass larvae, by considering the expression of several genes involved in morphogenesis. Fish were fed from 7 to 37 d post-hatch with five isoproteic and isolipidic compound diets incorporating different levels of EPA and DHA provided by phospholipid or neutral lipid. Phospholipid fraction containing 1 center dot 1 % (PL1 diet) to 2 center dot 3 % (PL3 diet) of EPA and DHA sustained good larval growth and survival, with low vertebral and cephalic deformities. Similar levels of EPA and DHA provided by the neutral lipid fraction were teratogenic and lethal. Nevertheless, dietary phospholipids containing high levels of DHA and EPA (PL5 diet)... Tipo: Text Palavras-chave: Retinoic acid receptors; Skeletal malformations; Dicentrarchus labrax larvae; Neutral lipids; Phospholipids. Ano: 2005 URL: http://archimer.ifremer.fr/doc/2005/publication-880.pdf Ketoconazole- and fluconazole-induced embryotoxicity and skeletal anomalies in wistar rats: a comparative study BABT Amaral,Vanessa Cristiane de Santana; Nunes Junior,Guilhermino Pereira. Ketoconazole and fluconazole are two broad-spectrum azole antifungals used for the treatment of superficial and systemic mycoses. Embryotoxicity and teratogenicity have been reported in some studies when those drugs are administered at high doses to pregnant rats. The aim of this study was to present a comparative study of embryotoxic effects as well as the skeletal anomalies in fetuses of Wistar rats which received ketoconazole and fluconazole at teratogenic doses on gestational days (GD) 6 through 15 (organogenesis period). On gestational day (GD) 21, the dams were euthanized and examined for standard parameters of reproductive outcome. Fetuses were stained with alizarin red and the bones of the head, trunk, forelimb and hindlimb were examined for... Tipo: Info:eu-repo/semantics/article Palavras-chave: Ketoconazole; Fluconazole; Maternal toxicity; Embryotoxicity; Skeletal malformations. Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000600010 Registros recuperados: 2 Primeira ... 1 ... Última

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