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	Provedor de dados BJPS (1) Autor Albuquerque,Sérgio de (1) Eloy,Josimar Oliveira (1) Marchetti,Juliana Maldonado (1) Saraiva,Juliana (1) Palavra-chave Chaga's Disease (1) Poloxamer 407 (1) Sodium caprate (1) Solid dispersions (1) Ursolic acid (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2015 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Preparation, characterization and evaluation of the in vivo trypanocidal activity of ursolic acid-loaded solid dispersion with poloxamer 407 and sodium caprate BJPS Eloy,Josimar Oliveira; Saraiva,Juliana; Albuquerque,Sérgio de; Marchetti,Juliana Maldonado. Ursolic acid is a promising candidate for treatment of Chagas disease; however it has low aqueous solubility and intestinal absorption, which are both limiting factors for bioavailability. Among the strategies to enhance the solubility and dissolution of lipophilic drugs, solid dispersions are growing in popularity. In this study, we employed a mixture of the surfactants poloxamer 407 with sodium caprate to produce a solid dispersion containing ursolic acid aimed at enhancing both drug dissolution and in vivo trypanocidal activity. Compared to the physical mixture, the solid dispersion presented higher bulk density and smaller particle size. Fourier Transform Infrared Spectroscopy results showed hydrogen bonding intermolecular interactions between drug and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Ursolic acid; Chaga's Disease; Solid dispersions; Poloxamer 407; Sodium caprate. Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000100101 Registros recuperados: 1 Primeira ... 1 ... Última

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