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| Silveira,Marina Bicalho; Soares,Marcella Araugio; Valente,Eduardo Sarmento; Waquil,Samira Soares; Ferreira,Andréa Vidal; Santos,Raquel Gouvêa dos; Silva,Juliana Batista da. |
| 18F-Sodium fluoride (Na18F) is a radiopharmaceutical used for diagnosis in nuclear medicine by positron emission tomography (PET) imaging. Bone scintigraphy is normally performed using 99mTc-MDP. However, 18F PET scans promise high quality imaging with increased resolution and improved sensitivity and specificity. In order to make available a tool for more specific studies of tumors and non-oncological diseases of bone tissue, the UPPR/CDTN team undertook the production and quality control of Na18F injectable solution with the physical-chemical, microbiological and biological characteristics recommended in the U.S. Pharmacopeia. Na18F radiochemical purity was 96.7 ± 1.3 %, with Rf= 0.026 ± 0.006. The product presented a pH of 5.3 ± 0.6, half life of 109.0... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Radiopharmaceuticals/biodistribution; Sodium fluoride 18F/production; Sodium fluoride 18F/quality control; Sodium fluoride. 18F/dosimetry; Bone imaging. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000300021 |
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