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	Provedor de dados 56 (1) 74 (1) Autor Antunes,Lusânia Maria Greggi (1) Braga,P.B.S. (1) Bronstein,M.D. (1) Corrêa-Giannella,M.L.C. (1) Fortes,M.A.H.Z. (1) Fragiorge,Edson José (1) Giorgi,R.R. (1) Murat,C.B. (1) Spanó,Mário Antônio (1) Mais... Palavra-chave Somatic mutation (2) Ascorbic acid (1) Doxorubicin (1) Drosophila melanogaster (1) Genomic amplification (1) Genotoxicity tests (1) PIK3CA proto-oncogene (1) Pituitary adenomas (1) Recombination test (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2012 (1) 2007 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Mutation and genomic amplification of the PIK3CA proto-oncogene in pituitary adenomas 56 Murat,C.B.; Braga,P.B.S.; Fortes,M.A.H.Z.; Bronstein,M.D.; Corrêa-Giannella,M.L.C.; Giorgi,R.R.. The tumorigenesis of pituitary adenomas is poorly understood. Mutations of the PIK3CA proto-oncogene, which encodes the p110-α catalytic subunit of PI3K, have been reported in various types of human cancers regarding the role of the gene in cell proliferation and survival through activation of the PI3K/Akt signaling pathway. Only one Chinese study described somatic mutations and amplification of the PIK3CA gene in a large series of pituitary adenomas. The aim of the present study was to determine genetic alterations of PIK3CA in a second series that consisted of 33 pituitary adenomas of different subtypes diagnosed by immunohistochemistry: 6 adrenocorticotropic hormone-secreting microadenomas, 5 growth hormone-secreting macroadenomas, 7 prolactin-secreting... Tipo: Info:eu-repo/semantics/article Palavras-chave: Pituitary adenomas; PIK3CA proto-oncogene; Genomic amplification; Somatic mutation. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000900009 Modulatory effects of the antioxidant ascorbic acid on the direct genotoxicity of doxorubicin in somatic cells of Drosophila melanogaster 74 Fragiorge,Edson José; Spanó,Mário Antônio; Antunes,Lusânia Maria Greggi. In this study two different crosses involving the wing cell markers mwh and flr³ (standard (ST) cross and high bioactivation (HB) cross, the latter being characterized by a high constitutive level of cytochrome P450 which leads to an increased sensitivity to a number of promutagens and procarcinogens) were used to investigate the modulatory effects of ascorbic acid (AA) combined with the antitumor agent doxorubicin (DXR) in Drosophila melanogaster. We observed that the two different concentrations of AA (50 or 100 mM) had no effect on spots frequencies, while DXR treatments (0.2 or 0.4 mM) gave positive results for all types of spots, when compared to negative control. For marker-heterozygous (MH) flies, a protective effect was observed with the lower... Tipo: Info:eu-repo/semantics/article Palavras-chave: Ascorbic acid; Doxorubicin; Drosophila melanogaster; Genotoxicity tests; Somatic mutation; Recombination test. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000300025 Registros recuperados: 2 Primeira ... 1 ... Última

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