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Oncogene-mediated downregulation of RECK, a novel transformation suppressor gene 56
Sasahara,R.M.; Takahashi,C.; Sogayar,M.C.; Noda,M..
The RECK gene was initially isolated as a transformation suppressor gene encoding a novel membrane-anchored glycoprotein and later found to suppress tumor invasion and metastasis by regulating matrix metalloproteinase-9. Its expression is ubiquitous in normal tissues, but undetectable in many tumor cell lines and in fibroblastic lines transformed by various oncogenes. The RECK gene promoter has been cloned and characterized. One of the elements responsible for the oncogene-mediated downregulation of mouse RECK gene is the Sp1 site, where the Sp1 and Sp3 factors bind. Sp1 transcription factor family is involved in the basal level of promoter activity of many genes, as well as in dynamic regulation of gene expression; in a majority of cases as a positive...
Tipo: Info:eu-repo/semantics/article Palavras-chave: RECK transformation suppressor gene; Reversion; Transcriptional regulation; Sp1 family; Tumor suppressor genes.
Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000700014
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