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	Provedor de dados BJPS (1) Autor Ashfaq,Muhammad (1) Khan,Islam Ullah (1) Mariam,Irfana (1) Razzaq,Syed Naeem (1) Razzaq,Syed Saleem (1) Palavra-chave Degradation products (1) Dexamethasone (1) RP-HPLC (1) Sparfloxacin (1) Stability studies (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2013 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Simultaneous RP-HPLC determination of sparfloxacin and dexamethasone in pharmaceutical formulations BJPS Razzaq,Syed Naeem; Ashfaq,Muhammad; Mariam,Irfana; Khan,Islam Ullah; Razzaq,Syed Saleem. The present study describes the development and subsequent validation of simple and accurate stability indicating RP-HPLC method for the determination of sparfloxacin and dexamethasone in pharmaceutical formulations in the presence of their stress-induced degradation products. Both the drugs and their stress-induced degradation products were separated within 10 minutes using C8 column and mixture of methanol and 0.02 M phosphate buffer pH 3.0 (60:40 v/v, respectively) as mobile phase at 270 nm using diode array detector. Regression analysis showed linearity in the range of 15-105 µg/mL for sparfloxacin and 5-35 µg/mL for dexamethasone. All the analytes were adequately resolved with acceptable tailing. Peak purity of the two drugs was also greater than... Tipo: Info:eu-repo/semantics/article Palavras-chave: RP-HPLC; Sparfloxacin; Dexamethasone; Degradation products; Stability studies. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000200012 Registros recuperados: 1 Primeira ... 1 ... Última

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