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Behavioral alterations induced by repeated saxitoxin exposure in drinking water J. Venom. Anim. Toxins incl. Trop. Dis.
Diehl,Felipe; Ramos,Patricia Baptista; Santos,Juliane Marques dos; Barros,Daniela Martí; Yunes,João Sarkis.
Abstract Background Blooms of the saxitoxin-producing cyanobacterium Cylindrospermopsis raciborskii have been contaminating drinking water reservoirs in Brazil for many years. Although acute effects of saxitoxin intoxication are well known, chronic deleterious outcomes caused by repeated saxitoxin exposure still require further investigation. The aim of the present work is to investigate the effects of consumption of drinking water contaminated with C. raciborskii for 30 days on learning and memory processes in rats. Methods The effects of saxitoxin (3 or 9 μg/L STX equivalents) or cyanobacteria on behavior was determined using the open field habituation task, elevated plus maze anxiety model task, inhibitory avoidance task, and referential Morris...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Saxitoxin; Drinking water; Behavior; Aversive memory; Spatial memory; Rats.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100314
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The modified 2VO ischemia protocol causes cognitive impairment similar to that induced by the standard method, but with a better survival rate BJMBR
Cechetti,F.; Worm,P.V.; Pereira,L.O.; Siqueira,I.R.; A. Netto,C..
Permanent bilateral occlusion of the common carotid arteries (2VO) in the rat has been established as a valid experimental model to investigate the effects of chronic cerebral hypoperfusion on cognitive function and neurodegenerative processes. Our aim was to compare the cognitive and morphological outcomes following the standard 2VO procedure, in which there is concomitant artery ligation, with those of a modified protocol, with a 1-week interval between artery occlusions to avoid an abrupt reduction of cerebral blood flow, as assessed by animal performance in the water maze and damage extension to the hippocampus and striatum. Male Wistar rats (N = 47) aged 3 months were subjected to chronic hypoperfusion by permanent bilateral ligation of the common...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Chronic cerebral hypoperfusion; Spatial memory; Hippocampus; Striatum; Water maze.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010001200007
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