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| Scremin,Amarilis; Piazzon,Monika; Silva,Marcos Antonio Segatto; Kuminek,Gislaine; Correa,Giane Márcia; Paulino,Niraldo; Cardoso,Simone Gonçalves. |
| Deflazacort (DFZ) is a glucocorticoid used as an anti-inflammatory and immunosuppressant drug. No official methods are available for DFZ determination in pharmaceutical formulations. The objective of this study was to develop, validate and compare spectrophotometric (UV and colorimetric) and high-performance liquid chromatography (HPLC) methods, for the quantitative determination of DFZ in tablets and oral suspension. For the UV method, ethanol was used as the solvent, with detection at 244 nm. The colorimetric method was based on the redox reaction with blue tetrazolium in alkaline medium, with detection at 524 nm. The method by HPLC was carried out using a C18 column, mobile phase consisting of acetonitrile:water (80:20, v/v) with a flow rate of 1.0 mL... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Deflazacort/quantitative determination; High performance liquid chromatography/quantitative analysis; Spectrophotometry/quantitative analysis; Medicines/quantitative analysis. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000200015 |
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| Vinay,Kanakapura Basavaiah; Revanasiddappa,Hosakere Doddarevanna; Devi,Okram Zenita; Ramesh,Pavagada Jagannathamurthy; Basavaiah,Kanakapura. |
| One titrimetric and two spectrophotometric methods have been described for the determination of ofloxacin (OFX) in bulk drug and in tablets, employing N-Bromosuccinimide as an analytical reagent. The proposed methods involve the addition of a known excess of NBS to OFX in acid medium, followed by determination of unreacted NBS. In titrimetry, the unreacted NBS is determined iodometrically, and in spectrophotometry, unreacted NBS is determined by reacting with a fixed amount of either indigo carmine (Method A) or metanil yellow (Method B). In all the methods, the amount of NBS reacted corresponds to the amount of OFX. Titrimetry allows the determination of 1-8 mg of OFX and the calculations are based on a 1:5 (OFX:NBS) reaction stoichiometry. In... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Ofloxacin/determination; Titrimetry/quantitative analysis; Spectrophotometry/quantitative analysis; N-Bromosuccinimide; Tablets/quantitative analysis. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000200006 |
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