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	Provedor de dados OceanDocs (1) BJPS (1) Autor Chen, Guangying (1) Lakshmi,P. K. (1) Lin, Yongcheng (1) Srivalli,Kale Mohana Raghava (1) Zhu, Feng (1) Palavra-chave Sphingolipids (2) Cluster of differentiation 243 (1) Competitive inhibitors (1) Metabolites (1) Multidrug resistence (1) P-glycoprotein/inhibitors (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Journal Contribution (1) Ano 2012 (1) 2007 (1) País Belgium (1) Brazil (1) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Overview of P-glycoprotein inhibitors: a rational outlook BJPS Srivalli,Kale Mohana Raghava; Lakshmi,P. K.. P-glycoprotein (P-gp), a transmembrane permeability glycoprotein, is a member of ATP binding cassette (ABC) super family that functions specifically as a carrier mediated primary active efflux transporter. It is widely distributed throughout the body and has a diverse range of substrates. Several vital therapeutic agents are substrates to P-gp and their bioavailability is lowered or a resistance is induced because of the protein efflux. Hence P-gp inhibitors were explored for overcoming multidrug resistance and poor bioavailability problems of the therapeutic P-gp substrates. The sensitivity of drug moieties to P-gp and vice versa can be established by various experimental models in silico, in vitro and in vivo. Ever since the discovery of P-gp, the... Tipo: Info:eu-repo/semantics/article Palavras-chave: P-glycoprotein/inhibitors; Multidrug resistence; Cluster of differentiation 243; Sphingolipids; Competitive inhibitors. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000300002 Structural Determination of Three Sphingolipids from Two Marine-derived Mangrove Endophytic Fungal Strains. OceanDocs Zhu, Feng; Chen, Guangying; Lin, Yongcheng. A set of three sphingolipids, N-2’-hydroxypalmitoyl-1-O-β-D-glucopyranosyl-9-methyl-4E, 8E-sphingadiene (A), N-2’-hydroxyl-3’E-octadecenoyl-1-O-β-D-glucopyranosyl-9-methyl-4E, 8Esphingadiene(B) and N-palmitoyldihydrosphingosine (C), were isolated from two marine-derived mangrove endophytic fungal strains (strains No. 1924 and 3893) from the South China Sea. Their structures were elucidated by 2D NMR and FABMS methods. It is the first time that these sphingolipids were separated and obtained from marine-derived mangrove endophytic fungus from the South China Sea. Tipo: Journal Contribution Palavras-chave: Metabolites; Sphingolipids. Ano: 2007 URL: http://hdl.handle.net/1834/5841 Registros recuperados: 2 Primeira ... 1 ... Última

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