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Decreased gastric emptying and gastrointestinal and intestinal transits of liquid after complete spinal cord transection in awake rats BJMBR
Gondim,F. de-A.A.; da-Graça,J.R.V.; de-Oliveira,G.R.; Rêgo,M.C.V.; Gondim,R.B.M.; Rola,F.H..
We studied the effect of complete spinal cord transection (SCT) on gastric emptying (GE) and on gastrointestinal (GI) and intestinal transits of liquid in awake rats using the phenol red method. Male Wistar rats (N = 65) weighing 180-200 g were fasted for 24 h and complete SCT was performed between C7 and T1 vertebrae after a careful midline dorsal incision. GE and GI and intestinal transits were measured 15 min, 6 h or 24 h after recovery from anesthesia. A test meal (0.5 mg/ml phenol red in 5% glucose solution) was administered intragastrically (1.5 ml) and the animals were sacrificed by an iv thiopental overdose 10 min later to evaluate GE and GI transit. For intestinal transit measurements, 1 ml of the test meal was administered into the proximal...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Gastric emptying; Gastrointestinal motility; Gastrointestinal transit; Intestinal transit; Rats; Spinal cord transection.
Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998001200015
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