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Implementation of vancomycin dosing nomogram in an electronic prescribing system: an innovative tool in antibiotic stewardship BJPS
Lima,Tácio de Mendonça; Elias,Sabrina Calil; Estrela,Rita de Cássia Elias; Cardoso,Fernando Luiz Lopes.
Vancomycin (VAN) is the gold standard therapy for Methicillin-resistant Staphylococcus aureus(MRSA) infections such as bacteremia and endocarditis. However, VAN suboptimal dosing for serious infections caused by S. aureus isolates that have elevated minimum inhibitory concentration (MIC), could be associated with poor outcome. Better understanding of VAN pharmacokinetics and pharmacodynamics (PK/PD) has led to the creation of new recommendations with optimized dosing regimens for the treatment of MRSA infections. For severe infectious, such as pneumonia and endocarditis, a VAN serum trough concentration of 15-20 mg/L at the steady state should be targeted. The aim of this study was to show how a nomogram with updated VAN dosing was devised and how it was...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Vancomycin/prescribing; Methicillin/use; Staphylococcus aureus/methicillin-resistant; Electronic prescribing system/application in hospital; Antibiotics/rational use; Antimicrobials/rational use.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000300567
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Prevalence of methicillin-resistant Staphylococcus aureus in a University Hospital in the South of Brazil BJPS
Rodrigues,Mônica de Abreu; Gindri,Lívia; Silva,Aniélen Dutra da; Guex,Camille Gaube; Santos,Silvana Oliveira dos; Hörner,Rosmari.
Methicillin-resistant Staphylococcus aureus (MRSA) stand out as one of the main agents causing nosocomial and community infections. This retrospective study aimed to analyze the MRSA predominance in a university hospital in the south of Brazil and it was carried out for five years (from 2007 to 2011). 616 MRSA (33,3% of the total) were isolated and an important reduction in the MRSA predominance was observed along the study. Although it was registered a reduction in the MRSA predominance, male adult patients (41-70 years old), who were in the Medical Clinic and Adult ICU, had the highest infection rates and concerning MRSA isolates rates, these were higher in blood and tracheal aspirates. In conclusion, studies of this type are becoming relevant to...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Staphylococcus aureus/methicillin-resistant; Resistant pathogens; Methicillin; University hospitals/infection.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000100035
Registros recuperados: 2
Primeira ... 1 ... Última
 

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