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Humoral immune alterations caused by lead: studies on an adult toad model Acta Toxicol. Argent.
Rosenberg,Carolina E.; Fink,Nilda E.; Salibián,Alfredo.
There is evidence that environmental metal levels affect the immune function. In the particular case of the impact of heavy metals, information available suggests that the immune system is a target for low-dose Pb exposure. Among vertebrates it was shown that amphibians are capable of forming antibodies against a variety of antigens, causing several responses such as anaphylactic response and rejecting grafts. In this study, the production of antibodies was assessed against sheep red blood cells (SRBC) in the anuran Bufo arenarum after six weekly injections of sublethal doses of lead (50 mg.kg-1, as lead acetate). Natural antibodies (natural heteroagglutinins) were also quantified against SRBC. Both assessments were carried out employing an ELISA method...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Sheep red blood cells (SRBC) antibodies; Heavy metals immunotoxicology; Sublethal lead; Bufo arenarum.
Ano: 2007 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1851-37432007000100003
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