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| Tahtinen, Petri; Guella, Graziano; Saielli, Giacomo; Debitus, Cecile; Hnawia, Edouard; Mancini, Ines. |
| Arsenicin A (C3H6As4O3) was isolated from the New Caledonian poecilosclerid sponge Echinochalina bargibanti, and described as the first natural organic polyarsenic compound. Further bioguided fractionation of the extracts of this sponge led us to isolate the first sulfur-containing organic polyarsenicals ever found in Nature. These metabolites, called arsenicin B and arsenicin C, are built on a noradamantane-type framework that is characterized by an unusual As-As bonding. Extensive NMR measurements, in combination with mass spectra, enabled the assignment of the structure for arsenicin B (C3H6As4S2) as 2. The scarcity of arsenicin C and its intrinsic chemical instability only allowed the collection of partial spectral data, which prevented the full... |
| Tipo: Text |
Palavras-chave: Antibacterial; Arsenical; Calculated NMR spectrum; Density functional theory; Natural products; NMR spectroscopy; Structure elucidation; Sulfur metabolite. |
| Ano: 2018 |
URL: https://archimer.ifremer.fr/doc/00469/58051/72242.pdf |
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