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| Rosa,Lorena de Sousa; Marques-Marinho,Flávia Dias; Braga,Silmara Leôncio; Souza,Jacqueline de. |
| The aim of this work was to perform solubility studies for fexofenadine hydrochloride and establish dissolution conditions for this drug in oral suspension dosage form. The solubility study was executed through the shake-flask method, below 37 ºC±1 ºC, at 100 rpm stirring for 12 h in three buffer solutions: hydrochloric acid pH 2.0, acetate pH 4.5 and phosphate pH 6.8. The dissolution test was developed in vessels containing 900 mL of the same buffer, employing the paddle apparatus in speed of 25 and 50 rpm, below 37 ºC±0.5 ºC. The drug was classified as low solubility according to the Biopharmaceutics Classification System, since the dose/solubility ratio was higher than 250 mL in all media tested (326.55 mL in buffer pH 2.0; 2,456.33 mL in buffer pH 4.5... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Fexofenadine hydrochloride; HPLC method; Biopharmaceutics; Suspension; Dissolution profile. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100585 |
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| Le Hir, Pierre; Cayocca, Florence; Waeles, Benoit. |
| Mixed sediments are constituted of cohesive and non-cohesive materials with distinct behaviours that numerical models traditionally manage separately. This paper first introduces a rapid state of the Art in sediment transport modelling in order to point out the specific requirements for process-based models applied to mixed sediments. Based on a preliminary study by Waeles et al. (2007), which showed the validity of the advection approach to compute fine sand transport, a complete modelling strategy is described: it is applied to the suspended transport of sand and mud mixtures, and accounts for consolidation of mixed sediments. Special care is paid to the realistic representation of the structure and density of sand and mud mixtures, and to the... |
| Tipo: Text |
Palavras-chave: Sediment transport modelling; Mixed sediment; Sand; Mud; Suspension; Consolidation. |
| Ano: 2011 |
URL: http://archimer.ifremer.fr/doc/00028/13952/12567.pdf |
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