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	Provedor de dados BJMBR (2) Autor Barata,J.T. (1) Burger,E. (1) Cardoso,B.A. (1) Gírio,A. (1) Henriques,C. (1) Martins,L.R. (1) Nishikaku,A.S. (1) Santos,C. (1) Silva,A. (1) Mais... Palavra-chave TGF-ß (2) Decorin (1) Granulomatous lesions (1) Jak/STAT (1) MAPK (1) Notch (1) PI3K/Akt (1) Paracoccidioides brasiliensis (1) Susceptibility and resistance (1) T-cell acute lymphoblastic leukemia (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2008 (1) 2003 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Immunohistochemical demonstration of TGF-ß and decorin in paracoccidioidal granulomas BJMBR Nishikaku,A.S.; Burger,E.. Different patterns of granulomas have been observed in 6- to 8-week-old mice after ip inoculation with 5 x 10(6) yeast cells of Paracoccidioides brasiliensis. Transforming growth factor-ß (TGF-ß) is a cytokine that has been shown to participate in fibrosis and granuloma formation; its activities seem to be modulated by the small proteoglycan decorin. In the present study, TGF-ß and decorin expression in epiploon granulomas was assessed by immunohistochemistry in susceptible (B10.A) and resistant (A/J) mice after 15, 30, 120 and 150 days of P. brasiliensis ip infection. The epiploon was collected, fixed in Methacarn solution and embedded in paraffin, and 5-µm thick sections were used for immunohistochemical analysis employing the... Tipo: Info:eu-repo/semantics/article Palavras-chave: TGF-ß; Decorin; Paracoccidioides brasiliensis; Granulomatous lesions; Susceptibility and resistance. Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000800014 Aberrant signaling in T-cell acute lymphoblastic leukemia: biological and therapeutic implications BJMBR Cardoso,B.A.; Gírio,A.; Henriques,C.; Martins,L.R.; Santos,C.; Silva,A.; Barata,J.T.. T-cell acute lymphoblastic leukemia (T-ALL) is a biologically heterogeneous disease with respect to phenotype, gene expression profile and activation of particular intracellular signaling pathways. Despite very significant improvements, current therapeutic regimens still fail to cure a portion of the patients and frequently implicate the use of aggressive protocols with long-term side effects. In this review, we focused on how deregulation of critical signaling pathways, in particular Notch, PI3K/Akt, MAPK, Jak/STAT and TGF-ß, may contribute to T-ALL. Identifying the alterations that affect intracellular pathways that regulate cell cycle and apoptosis is essential to understanding the biology of this malignancy, to define more effective markers for the... Tipo: Info:eu-repo/semantics/article Palavras-chave: T-cell acute lymphoblastic leukemia; Notch; PI3K/Akt; MAPK; Jak/STAT; TGF-ß. Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000500001 Registros recuperados: 2 Primeira ... 1 ... Última

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