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| Chai,S.D.; Liu,T.; Dong,M.F.; Li,Z.K.; Tang,P.Z.; Wang,J.T.; Ma,S.J.. |
| Pseudomonas aeruginosa is one of the common colonizing bacteria of the human body and is an opportunistic pathogen frequently associated with respiratory infections. Inactivated P. aeruginosa (IPA) have a variety of biological effects against inflammation and allergy. Transforming growth factor-β (TGF-β) signaling plays a critical role in the regulation of cell growth, differentiation, and development in a wide range of biological systems. The present study was designed to investigate the effects of IPA on TGF-β/Smad signaling in vivo, using a hypoxia-induced pulmonary hypertension (PH) rat model. Sprague Dawley rats (n=40) were exposed to 10% oxygen for 21 days to induce PH. At the same time, IPA was administered intravenously from day 1 to day 14. Mean... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Inactivated Pseudomonas aeruginosa; Pulmonary hypertension; TGF-β/Smad; Primary arterial smooth muscle cells; Α-smooth muscle actin. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016001000601 |
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