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| Fogaça,M.V.; Lisboa,S.F.; Aguiar,D.C.; Moreira,F.A.; Gomes,F.V.; Casarotto,P.C.; Guimarães,F.S.. |
| This paper presents an up-to-date review of the evidence indicating that atypical neurotransmitters such as nitric oxide (NO) and endocannabinoids (eCBs) play an important role in the regulation of aversive responses in the periaqueductal gray (PAG). Among the results supporting this role, several studies have shown that inhibitors of neuronal NO synthase or cannabinoid receptor type 1 (CB1) receptor agonists cause clear anxiolytic responses when injected into this region. The nitrergic and eCB systems can regulate the activity of classical neurotransmitters such as glutamate and γ-aminobutyric acid (GABA) that control PAG activity. We propose that they exert a ‘fine-tuning’ regulatory control of defensive responses in this area. This control, however, is... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Endocannabinoid; Anandamide; Nitric oxide; Endovanilloid; TRPV1. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000400010 |
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