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	Provedor de dados BABT (1) BJID (1) Autor Athayde,Margareth Linde (1) Beck,Ruy Carlos Ruver (1) Cardoso,Simone Gonçalves (1) Chavda,Jayant R. (1) Patel,Jayvadan K. (1) Palavra-chave Tablets (2) Antiretroviral therapy (1) Floating-bioadhesive (1) Glipizide (1) Lamivudine (1) Non-Fickian release (1) Public health (1) Quality control (1) Zidovudine (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2010 (1) 2007 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Formulation and evaluation of glipizide floating-bioadhesive tablets BABT Patel,Jayvadan K.; Chavda,Jayant R.. The purpose of this study was formulation and in vitro evaluation of floating-bioadhesive tablets to lengthen the stay of glipizide in its absorption area. Effervescent tablets were made using chitosan (CH), hydroxypropyl methylcellulose (HPMC), carbopolP934 (CP), polymethacrylic acid (PMA), citric acid, and sodium bicarbonate. Tablets with 5% effervescent base had longer lag time than 10%. The type of polymer had no significant effect on the floating lag time. All tablets floated atop the medium for 23-24 hr. Increasing carbopolP934 caused higher bioadhesion than chitosan (p < 0.05). All formulations showed a Higuchi, non-Fickian release mechanism. Tablets with 10% effervescent base, 80% CH/20% HPMC, or 80% CP/20% PMA seemed desirable. Tipo: Info:eu-repo/semantics/article Palavras-chave: Glipizide; Floating-bioadhesive; Tablets; Non-Fickian release. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132010000500010 HIV/AIDS treatment and physicochemical quality control of medicines: evaluation of non-generic lamivudine + zidovudine tablets manufactured in Brazil BJID Beck,Ruy Carlos Ruver; Athayde,Margareth Linde; Cardoso,Simone Gonçalves. In this work it was evaluated the physicochemical quality of lamivudine + zidovudine tablets, whose association belongs to the list of drugs distributed by the Brazil's National Program on Sexually Transmitted Diseases and AIDS. Four non-generic products (lamivudine + zidovudine tablets) were analyzed. They were obtained from different Brazilian manufacturers, besides a reference product. The quality was evaluated by physicochemical tests described in the official codes. A validated reversed-phase high performance liquid chromatography (HPLC) method was used for the assay of the active substances. All samples were in accordance to the requisites in relation to their physicochemical characteristics. Dissolution studies showed similar drug percentual... Tipo: Info:eu-repo/semantics/article Palavras-chave: Antiretroviral therapy; Quality control; Lamivudine; Public health; Tablets; Zidovudine. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000600003 Registros recuperados: 2 Primeira ... 1 ... Última

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