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| Zou,Meijuan; Wang,Caixia; Zhang,Xuezhu; Xu,Tao; Han,Jiarong; Zhang,Xiao; Cheng,Gang. |
| Our research has focused on the main design features and release performances of time-dependent colon-specific (TDCS) delivery tablets, which relies on the relative constancy that is observed in the small intestinal transit time of dosage forms. But inflammatory bowel disease（IBD）can affect the transit time, and usually results in watery stool. Compared to the TDCS and wax-matrix TDCS tablet, a promising time-dependent colon-specific delivery system was investigated. In our study, a suppository-base-matrix coated tablet was evaluated. Water soluble suppository-base helps the expansion of tablet, facilitates uniform film dissolution and achives high osmotic pressure. Combining the expansion of carboxymethyl starch sodium (CMS-Na) and the moisture... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Inflammatory bowel disease; Lonicera japonica Thunb/extract; Suppository/colon-specific delivery system; Drugs/colon-specific delivery system; Tablets/colon-specific delivery system. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000300535 |
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