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	Provedor de dados BJMBR (2) Autor Almeida,S.R. (1) Bonato,V.L.D. (1) Lima,V.M.F. (1) Lopes,J.D. (1) Silva,C.L. (1) Palavra-chave Th1/Th2 (2) Cytokines (1) DNA vaccination (1) Dendritic cells (1) Paracoccidioides brasiliensis (1) Paracoccidioidomycosis (1) Tuberculosis (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2001 (1) 1999 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última DNA encoding individual mycobacterial antigens protects mice against tuberculosis BJMBR Silva,C.L.; Bonato,V.L.D.; Lima,V.M.F.. Over the last few years, some of our experiments in which mycobacterial antigens were presented to the immune system as if they were viral antigens have had a significant impact on our understanding of protective immunity against tuberculosis. They have also markedly enhanced the prospects for new vaccines. We now know that individual mycobacterial protein antigens can confer protection equal to that from live BCG vaccine in mice. A critical determinant of the outcome of immunization appears to be the degree to which antigen-specific cytotoxic T cells are generated by the immune response. Our most recent studies indicate that DNA vaccination is an effective way to establish long-lasting cytotoxic T cell memory and protection against tuberculosis. Tipo: Info:eu-repo/semantics/article Palavras-chave: Tuberculosis; DNA vaccination; Cytokines; Th1/Th2. Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000200012 The low efficiency of dendritic cells and macrophages from mice susceptible to Paracoccidioides brasiliensis in inducing a Th1 response BJMBR Almeida,S.R.; Lopes,J.D.. In the present study we evaluated T cell proliferation and Th lymphokine patterns in response to gp43 from Paracoccidioides brasiliensis presented by isolated dendritic cells from susceptible and resistant mice. T cell proliferation assays showed that dendritic cells from susceptible mice were less efficient than those from resistant mice. The pattern of T cell lymphokines stimulated by dendritic cells was always Th1, although the levels of IL-2 and IFN-gamma were lower in T cell cultures from susceptible mice. To determie whether different antigen-presenting cells such as macrophages and dendritic cells stimulated different concentrations of Th1 lymphokines, the production of IFN-gamma and IL-2 was measured. It was observed that dendritic cells were more... Tipo: Info:eu-repo/semantics/article Palavras-chave: Dendritic cells; Paracoccidioidomycosis; Paracoccidioides brasiliensis; Th1/Th2. Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000400014 Registros recuperados: 2 Primeira ... 1 ... Última

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