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| Manterola,Carlos; Cartes-Velasquez,Ricardo; Otzen,Tamara. |
| The assessment of methodological quality (MQ) in biomedical research is an area of dynamic development over recent years globally. Understood as a complex and multidimensional construct, various groups have proposed tools for its assessment. Our team has designed and validated scales to assess MQ of therapy, diagnosis, and prognosis studies. However, as with other instruments, it is necessary to specify in detail how it is applied, in order to standardize the measurements made with this instrument. The aim of this article is to provide a guideline for the standardized application of the MInCir MQ scale for therapy or therapeutic procedure studies. A detailed description of the 3 domains and 6 items comprising the scale, specifying for each of them how to... |
| Tipo: Journal article |
Palavras-chave: Investigative Techniques; Methods/epidemiology methodological studies; Therapy; Intervention studies; Evaluation Studies as Topic; Epidemiologic Studies; Evidence-Based Medicine. |
| Ano: 2015 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000400045 |
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| THEAKSTON,R. D. G.; KAMIGUTI,A. S.. |
| Treatment of systemic envenoming in snakebite victims has, in the past, depended almost entirely on the individual clinician's experience in assessing the severity of envenoming. The efficacy of treatment is obviously related to the neutralising potency of the antivenom used, the route by which it is administered and the dose. The use of techniques for evaluating the efficacy of antivenoms has proved to be very useful, as an adjunct to recognised clinical observations, for a more objective evaluation of antivenom efficacy and dosage. In patients bitten by many vipers, including the Brazilian pit vipers, the reversal of the venom-induced coagulopathy provides an ideal indicator as to the efficacy of an antivenom. Likewise, the development of enzyme... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Snakebite; Therapy; Haemostasis; Enzyme immunoassay. |
| Ano: 1998 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79301998000200002 |
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| Sia,FY; Vejayan,J; Jamuna,A; Ambu,S. |
| In the present study, the effectiveness of Mimosa pudica tannins (MPT) in neutralizing the lethality of Naja kaouthia venom was compared with commercially derived tannins. Preincubation of MPT with N. kaouthia venom maintained 100% survival of mice after 24 hours. The mouse group in which there was no preincubation, no protection against the effects of the venom was observed. M. pudica tannin was found to be more effective in neutralizing the lethality of N. kaouthia venom when compared to commercial tannic acid. Two protein spots were missing in the two-dimensional gel electrophoresis (2-DE) of the MPT treated mouse indicating the down-regulation of venom proteins. The results from this study indicated that tannins obtained from M. pudica are better than... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Plant extract; Snake venom; Therapy; Tannin; Phospholipase A2. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992011000100006 |
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| SINGLA, L. D.; JUYAL, P. D.; SANDHU, B. S.. |
| Clinical hepatic coccidiosis in New Zealand white rabbits (n=24) of either sex (aged 1-2 month) with clinical signs, pathology an therapy is presented. The infected rabbits showed anorexia, reluctance to move and death within 3-4 days. Liver showed irregular whitish nodules scattered on its surface and in deeper parenchyma. Characteristic histopathologjcal changes in liver with different developmental stages of Eimeria stiedae in the epithelial cells of bile ducts have been recorded. Treatment of infected rabbits with 2.5% oltrazuril (Baycox) at 25 ppm in water for 2 days was highly effective. The oocysts is appeared in the faeces on day 6 after treatment. No mortality was seen in treated rabbits while all the infected untreated rabbits died with in a... |
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Palavras-chave: Eimeria stiedae; Therapy; Pathology; Rabbit. |
| Ano: 2000 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/131 |
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| Molina,L.R.; Diniz Neto,H.C.; Branco,R.S.P.C.; Lage,C.F.A.; Malacco,V.M.R.; Souza,F.N.; Diniz,S.A.; Gomes,G.S.; Silva,M.X.. |
| ABSTRACT 709 clinical mastitis cases were analyzed and treated with antimicrobial combination cephalexin-neomycin and the anti-inflammatory prednisolone. A sample of milk was collected to perform a microbiological culture before starting the treatment and 14 days later. Somatic cell count (SCC) was obtained from samples collected on the day of the clinical case (D0), 14 days after (D14) and 28 days after (D28). Of the total, 435 (61.4%) at the D0 exhibited growth of microorganisms. Of the isolated agents, 365 (84%) were Gram-positive, and 66 (16%) were Gram-negative. A clinical cure was achieved in 63% of cases. Bacteriological cure occurred in 75% of cases. Only at D28 after the clinical case a significant SCC reduction was verified. The logistic... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Clinical cure; Bacteriological cure; Therapy; Somatic cell count. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352018000601814 |
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| Valandro,M.A.; Pascon,J.P.E.; Pereira,D.T.P.; Mistieri,M.L.A.. |
| ABSTRACT The present study has the objective of evaluating the effects of exercise training, using moderate intensity walking (60 to 80% of maximum heart rate), from 30 to 50 minutes, three times a week, in alternate days, during eight weeks, on heart rate variability in dogs with myxomatous valve disease (MVD). For that, 20 dogs in stages B1 (1), B2 (14) and C2 (5) of MVD (ACVIM classification) were divided into untrained control group (CG, n=9) and training group (TG, n=11), and assessed at baseline (T0), after four (T1) and eight weeks (T2). Only one B1 and five B2 dogs completed the training program. In the time domain, the rMSSD was greater in TG in T1 (155,5+42,07) and T2 (199,8+83,54) than CG (T1:91,17+35,79 and T2:88,17+57,51). In the frequency... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Valvar endocardiosis; Therapy; Regular physical exercise; Autonomic balance. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352017000200325 |
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| Buscombe,John. R.. |
| Radiopeptides are playing an increasing role in the diagnosis of disease. Initially based on the somatatostatin system, early research concentrated on identifying tumours of neuroendocrine origin. New techniques with artificial peptides are extending their role into other areas such as thrombus formation and heart disease. It has been shown that radiopeptides have excellent labelling new methods have looked at therapy starting with high activities of In-111 pentetreotide to the development of Y-90 based products and new and novel peptides and radio isotopes. Outside of PET there are the most exciting developments in nuclear medicine. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Radiopeptides; Diagnosis; Therapy. |
| Ano: 2002 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132002000500013 |
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| Gonçales Jr.,Fernando Lopes; Vigani,Aline; Gonçales,Neiva; Barone,Antonio Alci; Araújo,Evaldo; Focaccia,Roberto; Oliveira,Umbeliana; Coelho,Henrique Sérgio Morais; Paixao,Jacqueline; Perez,Renata; Lobato,Cirley; Weirich,Judith; Rosa,Heitor; Borges,Andrelina; Vila,Ricardo; Corrêa-Giannella,Maria Lúcia; Ferraz,Maria Lúcia Gomes. |
| Combination therapy with pegylated interferon and ribavirin is considered the new standard therapy for naïve patients with chronic hepatitis C. We evaluated the efficacy and safety of treatment with weight-based peginterferon alpha-2b (1.5 mg/kg per week) plus ribavirin (800-1,200 mg/day) for 48 weeks in naïve, relapser and non-responder (to previous treatment with interferon plus ribavirin) patients with chronic hepatitis C. Sixty-seven naïve, 26 relapser and 40 non-responder patients were enrolled. The overall sustained virological response (SVR) for the intention-to-treat population was 54% for naïve, 62% for relapser and 38% for non-responder patients. In the naïve subgroup, SVR was significantly higher in patients with the non-1 genotype (67%)... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hepatitis C; Interferon alpha-2b; Therapy. |
| Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000500002 |
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| Marques,Luiz Paulo José; Flores,Juliana Timóteo; Barros Junior,Onofre de Oliveira; Rodrigues,Giovana Breda; Mourão,Carla de Medeiros; Moreira,Rosa Maria Portella. |
| BACKGROUND: Urinary tract infections (UTIs) in elderly patients can be a complex problem in terms of approach to diagnosis, treatment, and prevention, because the patients often present nonspecific symptoms. The epidemiological and clinical characteristics of UTI in elderly women were studied, in order to make early diagnosis and prevent serious clinical complications secondary to UTI. METHODS: This was a prospective population-based study, with elderly women, during their first medical office visit. Medical records were obtained by clinical history and physical examination in order to detect signs and symptoms of UTI and the presence of comorbidities. Clean-catch midstream urine specimens for urinary dipstick test, sediment, and culture were collected;... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Elderly women; Urinary tract infection; Asymptomatic bacteriuria; Risk factors; Therapy. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000500006 |
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| Wu,X.L.; Zhao,X.Q.; Zhang,B.X.; Xuan,F.; Guo,H.M.; Ma,F.T.. |
| Chediak-Higashi syndrome (CHS) is a rare autosomal recessive immunodeficiency disease characterized by frequent infections, hypopigmentation, progressive neurologic deterioration and hemophagocytic lymphohistiocytosis (HLH), known as the accelerated phase. There is little experience in the accelerated phase of CHS treatment worldwide. Here, we present a case of a 9-month-old boy with continuous high fever, hypopigmentation of the skin, enlarged lymph nodes, hepatosplenomegaly and lung infection. He was diagnosed with CHS by gene sequencing, and had entered the accelerated phase. After 8 weeks of therapy, the boy had remission and was prepared for allogenic stem cell transplantation. |
| Tipo: Info:eu-repo/semantics/report |
Palavras-chave: Chediak-Higashi syndrome; Accelerated phase; Gene sequencing; Therapy. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000400501 |
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| Registros recuperados: 21 | |
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