Home Itens selecionados Provedores de dados OAI Créditos Sobre Ajuda

			Busca avançada
	Provedor de dados BJMBR (1) BJPS (1) Autor Martins,N.F. (1) Mujahid,Mohammad (1) Rahman,Mohammad Akhlaquer (1) Santoro,M.M. (1) Palavra-chave Thermodynamic stability (2) Bioavailability (1) Intermediates (1) Molten globule (1) Oral delivery (1) Phase diagrams (1) Protein denaturation (1) SNEDDS (1) Solubility (1) Trypsinogen (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2018 (1) 1999 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Partially folded intermediates during trypsinogen denaturation BJMBR Martins,N.F.; Santoro,M.M.. The equilibrium unfolding of bovine trypsinogen was studied by circular dichroism, differential spectra and size exclusion HPLC. The change in free energy of denaturation was <img SRC="http:/img/fbpe/bjmbr/v32n6/3282sup.gif" ALIGN="BOTTOM" BORDER="0" VSPACE="0" HSPACE="0"> = 6.99 ± 1.40 kcal/mol for guanidine hydrochloride and <img SRC="http:/img/fbpe/bjmbr/v32n6/3282sup.gif" ALIGN="BOTTOM" BORDER="0" VSPACE="0" HSPACE="0"> = 6.37 ± 0.57 kcal/mol for urea. Satisfactory fits of equilibrium unfolding transitions required a three-state model involving an intermediate in addition to the native and unfolded forms. Size exclusion HPLC allowed the detection of an intermediate population of trypsinogen whose Stokes radii varied from 24.1 ± 0.4 Å to... Tipo: Info:eu-repo/semantics/article Palavras-chave: Trypsinogen; Protein denaturation; Thermodynamic stability; Intermediates; Molten globule. Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000600002 Development of self-nanoemulsifying tablet (SNET) for bioavailability enhancement of sertraline BJPS Rahman,Mohammad Akhlaquer; Mujahid,Mohammad. Abstract The purpose of the study was to combine the advantages of self-nanoemulsifying drug delivery systems and tablets as a conventional dosage form. Self-nanoemulsifying drug delivery system (SNEDDS) was prepared to enhance the solubility and thus oral bioavailability of sertraline. Aqueous titration method was used to prepare the liquid SNEDDS; ternary phase diagrams were constructed and based on smaller droplet size (24.8 nm), minimum viscosity (153.63 cP) and polydispersity index (0.182), higher percentage transmittance (95%) and in vitro drug release (97%), an optimum system was designated. Liquid SNEDDS was transformed into free-flowing powder by solid adsorption technique followed by compression into tablets. In vitro release of sertraline from... Tipo: Info:eu-repo/semantics/article Palavras-chave: SNEDDS; Phase diagrams; Solubility; Thermodynamic stability; Oral delivery; Bioavailability. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000100620 Registros recuperados: 2 Primeira ... 1 ... Última

Empresa Brasileira de Pesquisa Agropecuária - Embrapa Todos os direitos reservados, conforme Lei n° 9.610 Política de Privacidade Área restrita		Embrapa Parque Estação Biológica - PqEB s/n° Brasília, DF - Brasil - CEP 70770-901 Fone: (61) 3448-4433 - Fax: (61) 3448-4890 / 3448-4891 SAC: https://www.embrapa.br/fale-conosco