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	Provedor de dados BJMBR (2) BJID (1) Autor Boechat,L.H.B. (2) Zollner,R.L. (2) Andrade,Luis Jesuíno de Oliveira (1) Atta,Ajax Mercês (1) D'Almeida Junior,Argemiro (1) Paraná,Raymundo (1) Vilella,C.A. (1) Mais... Palavra-chave Thyroiditis (3) Apoptosis (1) Autoantibodies (1) Autoimmunity (1) Bcl-w mRNA (1) Fas mRNA (1) Fas-L mRNA (1) Hepatitis C (1) Interferon-alpha (1) Iodide (1) Methimazole (1) Nonobese diabetic mice (1) Proteases (1) Ribavirin (1) Thyroglobulin (1) Thyroid dysfunction (1) Trypsin (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Ano 2008 (1) 2002 (1) 1999 (1) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Thyroid dysfunction in hepatitis C individuals treated with interferon-alpha and ribavirin: a review BJID Andrade,Luis Jesuíno de Oliveira; Atta,Ajax Mercês; D'Almeida Junior,Argemiro; Paraná,Raymundo. Hepatitis C (HCV) is now the main cause of chronic hepatic disease, cirrhosis and hepatocellular carcinoma. Several extrahepatic diseases have been associated with chronic HCV infection, and in most cases appear to be directly related to the viral infection. Thyroid disorders are common in patients with chronic HCV. Some patients with chronic hepatitis C experience thyroid problems, and thyroid dysfunction may also be a side effect of interferon-based treatment. The principal risk factor for developing thyroid disease in the course of antiviral therapy is the previous positivity for anti-thyroid antibodies (anti-thyroid peroxidase) especially in older women. Screening for autoantibodies and serum thyroid-stimulating hormone is recommended before, during... Tipo: Info:eu-repo/semantics/article Palavras-chave: Hepatitis C; Interferon-alpha; Ribavirin; Thyroid dysfunction; Thyroiditis. Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000200009 Reactivity of anti-thyroid antibodies to thyroglobulin tryptic fragments: comparison of autoimmune and non-autoimmune thyroid diseases BJMBR Boechat,L.H.B.; Zollner,R.L.. Studies concerning the antigenicity of thyroglobulin fragments allow the characterization of the epitopes but do not consider the role of heavier antigenic fragments that could result in vivo from the action of endoproteases. Here we assess the relative importance of the fragments obtained from thyroglobulin by limited proteolysis with trypsin and compare by immunoblotting their reactivity to serum from patients with autoimmune (Graves' disease and Hashimoto's thyroiditis) and non-autoimmune (subacute thyroiditis) disease. The results showed no difference in frequency of recognition of any peptide by sera from patients with autoimmune thyroiditis. In contrast, sera from patients with subacute thyroiditis reacted more frequently with a peptide of 80 kDa.... Tipo: Info:eu-repo/semantics/article Palavras-chave: Autoantibodies; Autoimmunity; Thyroglobulin; Trypsin; Thyroiditis; Proteases. Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000400012 Effect of iodide on Fas, Fas-ligand and Bcl-w mRNA expression in thyroid of NOD mice pretreated with methimazole BJMBR Boechat,L.H.B.; Vilella,C.A.; Zollner,R.L.. Nonobese diabetic (NOD) mice and a derived strain, NOD.H.2h4, have been used as a model for experimental spontaneous thyroiditis and thyroiditis induced by iodide excess after a goiter-inducing period. Some authors have proposed that iodide, given after methimazole or propylthiouracil, is capable of inducing apoptosis in thyroid cells and that anti-thyroid drugs can modulate the expression of apoptosis components such as Fas and its ligand (Fas-L). Here we evaluated the effect of potassium iodide (20 µg/animal for 4 days, ip) given to NOD mice at the 10th week of life after exposure to methimazole (1 mg/ml) in drinking water from the 4th to the 10th week of life. Fas, Fas-L and Bcl-w expression were analyzed semiquantitatively by RT-PCR immediately after... Tipo: Info:eu-repo/semantics/article Palavras-chave: Thyroiditis; Nonobese diabetic mice; Apoptosis; Methimazole; Iodide; Fas mRNA; Fas-L mRNA; Bcl-w mRNA. Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000300003 Registros recuperados: 3 Primeira ... 1 ... Última

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