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Invasive aspergillosis in hematopoietic stem cell transplant recipients: a retrospective analysis BJID
Carvalho-Dias,Viviane Maria Hessel; Sola,Caroline Bonamin Santos; Cunha,Clóvis Arns da; Shimakura,Sílvia Emiko; Pasquini,Ricardo; Queiroz-Telles,Flávio de.
Invasive aspergillosis (IA) currently is an important cause of mortality in subjects undergoing hematopoietic stem cell transplants (HSCT) and is also an important cause of opportunistic respiratory and disseminated infections in other types of immunocompromised patients. We examined the medical records of 24 cases of proven and probable invasive aspergillosis (IA) at the Hospital de Clinicas of the Federal University of Parana, Brazil, from January 1996 to October 2006. During this period occurred a mean of 2.2 cases per year or 3.0 cases per 100 HSTC transplants. There was a significant relationship between structural changes in the bone marrow transplant (BMT) Unit and the occurrence of IA cases (p=0.034, relative risk (RR) = 2.47). Approximately 83% of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Invasive aspergillosis; Transplant recipients; Immunocompromised.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000500008
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Impairment of cytomegalovirus-specific cellular immune response as a risk factor for cytomegalovirus disease in transplant recipients BJMBR
Motta,V.N; Martins,S.L.R.
Human cytomegalovirus (CMV) infection is common in most people but nearly asymptomatic in immunocompetent individuals. After primary infection the virus persists throughout life in a latent form in a variety of tissues, particularly in precursor cells of the monocytic lineage. CMV reinfection and occurrence of disease are associated with immunosuppressive conditions. Solid organ and bone marrow transplant patients are at high risk for CMV disease as they undergo immunosuppression. Antiviral treatment is effective in controlling viremia, but 10-15% of infected patients can experience CMV disease by the time the drug is withdrawn. In addition, long-term antiviral treatment leads to bone marrow ablation and renal toxicity. Furthermore, control of chronic CMV...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cytomegalovirus infection; T-cell responses; Transplant recipients; Intracellular cytokines.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000100002
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