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| Pinto,MCL; Melo,MB; Cruz,ML; Verçosa Junior,D; Melo,MM. |
| Accidental envenomation caused by Tityus serrulatus scorpions is very common in Brazil and may result in serious cardiorespiratory alterations that are frequently fatal to children. In the present study, the effects of T. serrulatus venom on the cardiorespiratory system of recently weaned male Wistar rats were evaluated. Fifteen animals were distributed into three groups (n = 5). The control group A received 400 μL ultrapure water by subcutaneous injection, while the experimental groups B and C were injected with scorpion venom (100 and 450 μg, respectively, in 400 μL water). Electrocardiogram (ECG) traces were obtained prior to the experiment, at five-minute intervals up to 30 minutes after treatment. At 40 minutes after envenomation, the animals had... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Tityus serrulatus; Rats; Electrocardiography; CK; CK-MB; Troponin; Pulmonary hemorrhages. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992010000200008 |
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| Zayerzadeh,E; Koohi,MK; Zare Mirakabadi,A; Purkabireh,M; Kassaaian,SE; Rabbani,SH; Sotoudeh Anvari,M; Boroumand,MA; Sadeghian,S. |
| Scorpion envenomation is a life-threatening condition, especially in children and elderly individuals affected by respiratory and cardiovascular diseases. In this study, the toxic effects of median lethal dose (LD50) injections of Mesobuthus eupeus (Me) venom on the heart and lungs of anesthetized rabbits were investigated. Six rabbits were selected and alterations in their electrocardiogram, heart rate, respiration and blood pressure before and after venom injection were recorded. Cardiac troponin T (cTnT), creatinine kinase muscle-brain fraction (CK-MB) and lactate dehydrogenase (LDH) were measured at 0, 1 and 3 hours after envenomation and pathology studies were carried out postmortem. All the animals showed signs and symptoms of envenomation within 40... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Mesobuthus eupeus; Scorpion experimental envenomation; Histopathological changes; Electrocardiogram changes; Troponin. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992010000100006 |
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