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Última DETECCIÓN DE INFECCIÓN NATURAL POR Trypanosoma cruzi (TRYPANOSOMATIDAE) EN TRIATOMINOS DEL MUNICIPIO DE COLOSÓ, COLOMBIA Acta biol.Colomb. AYALA HOYOS,Carolina Julieth; HERNÁNDEZ MENDOZA,Carlos Mario; EYES ESCALANTE,Melissa; ROMERO RICARDO,Luis Roberto; ÁLVAREZ RODRÍGUEZ,Rafael Andrés; BLANCO TUIRÁN,Pedro. RESUMEN El reporte de triatominos infectados por Trypanosoma cruzi en un área silvestre del municipio de Colosó, hizo necesario determinar las especies de vectores en cercanía a las viviendas de la vereda Jorro, por ser el asentamiento rural próximo al hallazgo. En la presente nota, se informa por primera vez para el municipio la presencia de especies de triatominos de importancia epidemiológica con un alto porcentaje de infección por el parásito, además, de ampliar la distribución de estos vectores en el departamento de Sucre. Para ello, se realizaron capturas de los insectos en 13 viviendas por búsqueda activa, vigilancia comunitaria y trampas de luz. La determinación de la infección natural se llevó a cabo por observación directa al microscopio y... Tipo: Info:eu-repo/semantics/article Palavras-chave: Colosó; Enfermedad de Chagas; Infección; Triatominos; Trypanosoma cruzi; Vectores. Ano: 2019 URL: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0120-548X2019000100180 INFECCIÓN NATURAL POR Trypanosoma cruzi (TRYPANOSOMATIDAE) EN TRIATOMINOS INTRADOMÉSTICOS DEL DEPARTAMENTO DE GUAINÍA Acta biol.Colomb. SOLÍS-MEDINA,Cesil; ZULUAGA AGUIRRE,Sara; TRIANA-CHAVEZ,Omar; CANTILLO-BARRAZA,Omar. RESUMEN La búsqueda continua de triatominos forma parte de los programas de vigilancia de la enfermedad de Chagas en zonas con características ecológicas apropiadas para la presencia del vector, permitiendo priorizar y definir las acciones de intervención. El objetivo del presente trabajo fue determinar la presencia y estado de infección de triatominos en viviendas del municipio de Inírida (Guainía). El estudio se realizó entre 2018 y 2019 mediante vigilancia comunitaria y búsqueda activa. Los vectores se identificaron y evaluaron por PCR. Se recolectaron cinco triatominos (un Panstrongylus lignarius y cuatro P. geniculatus). Se evidenció la infección natural en ambas especies. La genotipificación mostró la presencia de TcI Dom. Se actualiza así la... Tipo: Info:eu-repo/semantics/article Palavras-chave: Enfermedad de Chagas; Panstrongylus geniculatus; Panstrongylus lignarius; Triatominos; Trypanosoma cruzi. Ano: 2021 URL: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0120-548X2021000100127 Metabolismo del hemo: las dos caras de los efectos de la acumulación de precursores y porfirinas ABCL Rossetti,María Victoria; Buzaleh,Ana María; Parera,Victoria Estela; Fukuda,Haydée; Lombardo,María Elisa; Lavandera,Jimena; Gerez,Esther Noemí; Melito,Viviana Alicia; Zuccoli,Johanna Romina; Ruspini,Silvina Fernanda; Puente,Vanesa Rocío; Diez,Berenice Andrea; Teijo,María Julieta; Cerbino,Gabriela Nora; Varela,Laura Sabina; Néstor Guolo,Marcelo; Batlle,Alcira María del Carmen. Las porfirias son enfermedades metabólicas consecuencia de fallas en la biosíntesis del hemo, caracterizadas por un patrón específico de acumulación y excreción de intermediarios, responsables de su patofisiología. En las porfirias agudas el exceso de ácido d-aminolevúlico (ALA) produce una sintomatología neuroabdominal asociada al daño oxidativo por formación de especies reactivas de oxígeno (ROS), originadas por autooxidaxión del ALA. En las cutáneas, la sintomatología es producto de la acumulación de porfirinas, que como el ALA, inducen la formación de ROS. Su desencadenamiento se precipita por factores endógenos (ayuno, estrés, hormonas) y/o exógenos (fármacos), en particular algunos anestésicos. Se presenta una revisión de los estudios bioquímicos y... Tipo: Info:eu-repo/semantics/article Palavras-chave: Metabolismo del hemo; Porfirias; Porfirinas; Ácido d-aminolevúlico; Anestésicos volátiles; Terapia fotodinámica; Trypanosoma cruzi. Ano: 2016 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0325-29572016000400005 Detección de Trypanosoma cruzi en tejido y sangre murina por PCR convencional y en tiempo real ABCL Davies,Carolina; Poma,Ramiro Hugo; Marino Cardozo,Rubén; Mora,María Celia; Ramos,Federico; Rajal,Verónica Beatriz; Basombrío,Miguel Ángel. El objetivo del presente trabajo fue comparar la detección de ADN de Trypanosoma cruzi mediante PCR en tiempo real (qPCR) y PCR convencional en sangre periférica (n=25) y músculo esquelético (n=20) de ratones tratados con drogas tripanomicidas luego de 6 meses post-tratamiento. En las muestras de sangre se detectaron un total de 7 positivas por qPCR, mientras que por PCR convencional sólo se detectaron 2. En músculo esquelético, 15 muestras fueron positivas por qPCR y 3 por PCR convencional. Los resultados obtenidos demuestran que la fuerza de concordancia es débil entre las técnicas de PCR utilizadas para la detección de ADN de T. cruzi (k=0,37; 49% positivas por qPCR vs. 11% por PCR convencional, p=0,0001). En las muestras de sangre, los valores... Tipo: Info:eu-repo/semantics/article Palavras-chave: PCR convencional; PCR en tiempo real; Ratones; Carga parasitaria; Sangre periférica; Músculo esquelético; Trypanosoma cruzi. Ano: 2014 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0325-29572014000400004 Prevalencia de infección por Trypanosoma cruzi en escolares de Salta y Chaco, Argentina ABCL Sánchez Negrette,Olga; Zaidenberg,Mario; Monteros,María Concepción; Acevedo,Analía; Linares,Víctor; Freilij,Héctor. El objetivo del trabajo consistió en identificar la seroprevalencia de la infección por Trypanosoma cruzi en niños en edad escolar en localidades de las provincias de Salta y Chaco. Se trabajó en 44 escuelas de la ciudad de Salta, en parajes de San Carlos; en 10 escuelas de La Unión y en 7 escuelas de Taco Pozo. El trabajo tiene un diseño de corte transversal. La toma de muestra se realizó por punción capilar con equipos Serokit, y la confirmación de los casos seropositivos o dudosos por punción venosa, y obtención de suero, para realizar HAI y ELISA. Los casos seropositivos confirmados fueron tratados con Benznidazol® durante 60 días en dosis de 5-7mg/kg/ día. Para el análisis estadístico se elaboraron tablas con frecuencias absolutas y relativas. Se... Tipo: Info:eu-repo/semantics/article Palavras-chave: Seroprevalencia; Trypanosoma cruzi; Escolares; Salta; Chaco; Vectores. Ano: 2017 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0325-29572017000400016 Diagnóstico de infección por Trypanosoma cruzi en Centros de Atención Primaria de Salta, Argentina ABCL Sánchez Negrette,Olga; Monteros,María Concepción; Davies,Carolina; Zaidenberg,Mario Oscar. La Enfermedad de Chagas causada por el parásito hemoflagelado Trypanosoma cruzi, constituye un grave problema de Salud Pública. En Argentina, se controla sistemáticamente la sangre a transfundir, la donación de órganos y se ha disminuido notablemente la transmisión vectorial. El objetivo de este proyecto fue implementar el uso del equipo para recolección de sangre capilar y conservación en glicerina (Serokit) en los servicios de enfermería de los Centros de Atención Primaria de la Salud en la ciudad de Salta a fin de conocer la seroprevalencia de infección por Trypanosoma cruzi en pacientes que concurren a los mismos. Para ello se realizó el par serológico HAI y ELISA en las muestras conservadas en Serokit y luego en muestras de sangre tomadas por punción... Tipo: Info:eu-repo/semantics/article Palavras-chave: Atención primaria de salud; Enfermedad de Chagas; Serología; Niños; Trypanosoma cruzi; Prevención y control. Ano: 2013 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0325-29572013000400008 Avaliação da atividade anti-Leishmania e anti-Trypanosoma do extrato etanólico das folhas de Annona squamosa L Acta Toxicol. Argent. Sobreira Dantas Nóbrega de Figuêiredo,Francisco Rodolpho; Gyllyandeson,de Araújo Delmondes; Paulo da Cruz,Luzia; Amaro do Nascimento,Érika; Relison Tintino,Saulo; Santiago Lemos,Izabel Cristina; Bezerra da Cunha,Francisco Assis; Vega Gomez,Maria Celeste; Coronel,Cathia; Martins da Costa,José Galberto; Melo Coutinho,Henrique Douglas; Bezerra Felipe,Cícero Francisco; Alencar de Menezes,Irwin Rose; Kerntopf,Marta Regina. As doenças parasitárias, também chamadas de &#8220;doenças negligenciadas&#8221;, continuam sendo uma grande dificuldade para o desenvolvimento social e econômico dos países mais pobres. Podemos citar como exemplo dessas doenças, a leishmaniose e a doença de Chagas. A leishmaniose é causada por parasitas do gênero Leishmania e afeta cerca de 12 milhões de pessoas. A doença de Chagas, causada pelo protozoário Trypanosoma cruzi, causa aproximadamente 50.000 mortes por ano. Os fármacos disponíveis para o tratamento dessas doenças são altamente tóxicos, sendo este um dos motivos que leva à busca por drogas eficazes e seguras para seus tratamentos. As folhas da Annona squamosa, espécie da família Annonaceae, já foram descritas na literatura por suas... Tipo: Info:eu-repo/semantics/article Palavras-chave: Annona squamosa; Annonaceae; Leishmania; Trypanosoma cruzi. Ano: 2016 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1851-37432016000300001 The pathogenesis of Chagas' disease: when autoimmune and parasite-specific immune responses meet Anais da ABC (AABC) SOARES,MILENA B. P.; PONTES-DE-CARVALHO,LAIN; RIBEIRO-DOS-SANTOS,RICARDO. Chagas' disease is a major health problem in Latin America, where it constitutes one of the leading causes of heart failure. About one fourth of Trypanosoma cruzi-infected individuals develop chronic chagasic cardiomyopathy (CChC), the most severe form of the disease. CChC is histologically characterized by the presence of multifocal inflammatory infiltrates in the heart, composed mainly by mononuclear cells, usually adhered to myocytes and leading to myocytolysis, and frequently by interstitial fibrosis. The pathogenesis of CChC is still unclear, despite intense investigations both in human beings and in animal models of the disease. Although tissue parasitism is rare in the chronic phase of infection, an immune response targeted to persistent parasites... Tipo: Info:eu-repo/semantics/article Palavras-chave: Chagas' disease; Myocarditis; Autoimmunity; Trypanosoma cruzi; Delayed-type hypersensitivity. Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652001000400008 In vitro antiparasitic activity and chemical composition of the essential oil from Protium ovatum leaves (Burceraceae) Anais da ABC (AABC) ESTEVAM,ELISÂNGELA B.B.; DEUS,ISABELLA P.B. DE; SILVA,VANESSA P. DA; SILVA,ELIZABETH A.J. DA; ALVES,CASSIA C.F.; ALVES,JOSÉ MILTON; CAZAL,CRISTIANE M.; MAGALHÃES,LIZANDRA G.; PAGOTTI,MARIANA C.; ESPERANDIM,VIVIANE R.; SOUZA,ALEX F.; MIRANDA,MAYKER L.D.. ABSTRACT Leishmaniasis and trypanosomiasis are globally widespread parasitic diseases which have been responsible for high mortality rates. Since drugs available for their treatment are highly hepatotoxic, nephrotoxic and cardiotoxic, adherence to therapy has been affected. Thus, the search for new, more effective and safer drugs for the treatment of these diseases is necessary. Natural products have stood out as an alternative to searching for new bioactive molecules with therapeutic potential. In this study, the chemical composition and antiparasitic activity of the essential oil from Protium ovatum leaves against trypomastigote forms of Trypanosoma cruzi and the promastigote forms of Leishmania amazonensis were evaluated. The essential oil was promising... Tipo: Info:eu-repo/semantics/article Palavras-chave: Trypanosoma cruzi; Leishmania amazonensis; Essential oil; Protium ovatum; Parasitic diseases. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000603005 Susceptible hosts: a resort for parasites right in the eye of the immune response Anais da ABC (AABC) DOSREIS,GEORGE A.. Trypanosomatid protozoan parasites express an aggressive strategy of parasitism by infecting host macrophages and inducing extensive T-lymphocyte activation. One goal of such strategy is to drive the immune response of genetically susceptible hosts to a state of unresponsiveness regarding parasite killing. Unresponsiveness is achieved through different mechanisms, depending on the parasite species. In this brief review, recent findings on the molecular and cellular bases of the parasites' exploitation of host immune responses are discussed. Tipo: Info:eu-repo/semantics/article Palavras-chave: Trypanosoma cruzi; Leishmania chagasi; T lymphocytes; CTLA-4; Apoptosis; Transforming growth factor. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652000000100011 Mammalian cell invasion and intracellular trafficking by Trypanosoma cruzi infective forms Anais da ABC (AABC) Mortara,Renato A.; Andreoli,Walter K.; Taniwaki,Noemi N.; Fernandes,Adriana B.; Silva,Claudio V. da; Fernandes,Maria Cecília D.C.; L'abbate,Carolina; Silva,Solange da. Trypanosoma cruzi, the etiological agent of Chagas’ disease, occurs as different strains or isolates that may be grouped in two major phylogenetic lineages: T. cruzi I, associated with the sylvatic cycle and T. cruzi II, linked to the human disease. In the mammalian host the parasite has to invade cells and many studies implicated the flagellated trypomastigotes in this process. Several parasite surface components and some of host cell receptors with which they interact have been identified. Our work focused on how amastigotes, usually found growing in the cytoplasm, can invade mammalian cells with infectivities comparable to that of trypomastigotes. We found differences in cellular responses induced by amastigotes and trypomastigotes regarding... Tipo: Info:eu-repo/semantics/article Palavras-chave: Trypanosoma cruzi; Cellular invasion; Amastigotes; Trypomastigotes; Parasitophorous vacuole escape; Trafficking; Coxiella burnetii; Phylogenetic lineages. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652005000100006 Correlation between infection rate of triatominies and Chagas Disease in Southwest of Bahia, Brazil: a warning sign? Anais da ABC (AABC) SILVEIRA,ELIEZER A. DA; RIBEIRO,ISRAEL S.; AMORIM,MIGUEL S.; ROCHA,DALVA V.; COUTINHO,HELDER S.; FREITAS,LEANDRO M. DE; TOMAZI,LAIZE; SILVA,ROBSON A.A. DA. ABSTRACT Chagas disease, caused by the Trypanosoma cruzi, has a wide distribution in South America, and its main method of control is the elimination of triatomines. It is presented here the geographic distribution and the rate of natural infection by T. cruzi of triatomines collected and evaluated from 2008 to 2013 in southwest of Bahia. Triatomines were captured in the intradomiciliary and peridomiciliary areas of five cities located in the southwest of Bahia state, identified, and analyzed for the presence of trypanosomatids in their feces. During the study period the number of patients suspected for acute Chagas disease was recovered from the Notifiable Diseases Information System (SINAN). 8966 triatomines were captured and identified as belonging to... Tipo: Info:eu-repo/semantics/article Palavras-chave: Infection; Chagas disease; Trypanosoma cruzi; Vector. Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000501941 Balanced cytokine-producing pattern in mice immunized with an avirulent Trypanosoma cruzi Anais da ABC (AABC) Soares,Milena B. P.; Gonçalves,Renata; Pyrrho,Alexandre S.; Costa,Deise A.; Paiva,Claudia N.; Gattass,Cerli R.. We have previously demonstrated that inoculation of BALB/c mice with trypomastigotes of CL-14, an avirulent Trypanosoma cruzi clone, prevents the development of parasitemia and mortality after challenge with virulent CL strain. In this report, we investigated the cytokine and antibody profiles induced by inoculation with CL-14 clone. Groups of mice were inoculated with trypomastigotes of CL-14 clone and challenged with infective CL strain. Challenged CL-14-inoculated mice had lower levels of IFN-<FONT FACE=Symbol>g</font> and higher production of IgG1 antibodies as compared to CL strain-infected mice. Previous inoculation with CL-14 clone partially prevented the suppression of IL-2 production caused by CL strain infection. No significant... Tipo: Info:eu-repo/semantics/article Palavras-chave: Trypanosoma cruzi; Protection; Cytokines; Humoral response. Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652003000200005 In vitro trypanocidal activity of solamargine and extracts from Solanum palinacanthum and Solanum lycocarpum of brazilian cerrado Anais da ABC (AABC) MOREIRA,RAQUEL R.D.; MARTINS,GILMARCIO Z.; MAGALHÃES,NATHÁLIA O.; ALMEIDA,ADÉLIA E.; PIETRO,ROSEMEIRE C.L.R.; SILVA,FLÁVIA A. J.; CICARELLI,REGINA M.B.. The present investigation was to evaluate the potential trypanocidal activity of crude ethanolic extract of the fruits of Solanum palinacanthum, Solanum lycocarpum and the glycoalcaloid, solamargine. S. palinacanthum and S. lycocarpum fruit powders were submitted to exhaustively extraction with 96% ethanol and solamargine were isolated from the extract of S. palinacanthum. Both extracts and solamargine were analysed for trypanocidal activity by using MTT colorimetric assay. Extracts of S. palinacanthum showed to be more active (IC50 = 175.9 µg.ml–1) than S. lycocarpum (IC50 = 194.7 µg.ml–1). Solamargine presented a strong activity (IC50 = 15.3 µg.ml–1), which can explain the better activity of the both extracts. Benznidazol (IC50 = 9.0 µg.ml–1) is the only... Tipo: Info:eu-repo/semantics/article Palavras-chave: Solanum palinacanthum; Solanum lycocarpum; Solamargine; Epimastigote; Antitrypanosomal activity; Trypanosoma cruzi. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652013000300903 Inositol metabolism in Trypanosoma cruzi: potential target for chemotherapy against Chagas' disease Anais da ABC (AABC) OLIVEIRA,MECIA M.; EINICKER-LAMAS,MARCELO. Chagas' disease is a debilitating and often fatal disease caused by the protozoan parasite Trypanosoma cruzi. The great majority of surface molecules in trypanosomes are either inositol-containing phospholipids or glycoproteins that are anchored into the plasma membrane by glycosylphosphatidylinositol anchors. The polyalcohol myo-inositol is the precursor for the biosynthesis of these molecules. In this brief review, recent findings on some aspects of the molecular and cellular fate of inositol in T. cruzi life cycle are discussed and identified some points that could be targets for the development of parasite-specific therapeutic agents. Tipo: Info:eu-repo/semantics/article Palavras-chave: Inositol; Trypanosoma cruzi; Chagas' disease; Chemotherapy. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652000000300015 Two special organelles found in Trypanosoma cruzi Anais da ABC (AABC) SOUZA,WANDERLEY DE; CARREIRO,ISABEL PORTO; MIRANDA,KILDARE; SILVA,NARCISA L. CUNHA E. We review here two unique organelles from Trypanosoma cruzi. One of them is the acidocalcisome, cytoplasmic vacuoles containing a very high Ca2+ concentration and a Ca2+ - H+ translocating ATPase activity, present in all trypanosomatids. The other organelle is the reservosome, site of accumulation of endocytosed macromolecules, very rich in cysteine proteinase, that is present only in epimastigote forms of trypanosomes belonging to the Schyzotrypanum sub-genus. Tipo: Info:eu-repo/semantics/article Palavras-chave: Acidocalcisome; Reservosome; Trypanosoma cruzi. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652000000300016 Effect of acetylsalicylic acid on total myenteric neurons in mice experimentally infected with Trypanosoma cruzi Anais da ABC (AABC) SOUZA,NOEMI D. DE; BELIN,BRUNA S.; MASSOCATTO,CRISTINA L.; ARAÚJO,SILVANA M. DE; SANT’ANA,DÉBORA M.G.; ARAÚJO,EDUARDO J.A.; P. FILHO,PHILENO; NIHEI,OSCAR K.; MOREIRA,NEIDE M.. Abstract: We investigated the effects of acetylsalicylic acid (ASA) on the total myenteric neuronal population in the descending colon in Trypanosoma cruzi-infected mice. Thirty-five male Swiss mice, 60 days old, were divided into a control group (C group), control group treated with ASA (CA group), infected group (I group), and infected group treated with ASA (IA group). A total of 1300 trypomastigotes of the Y strain of T. cruzi were intraperitoneally inoculated in the IA and I groups. The CA and IA groups were treated with ASA intraperitoneally. At 75 days post-infection (dpi), all of the animals were sacrificed. Neurons in the colon were stained with Giemsa, quantified, and measured. No difference in the course of infection was observed between the IA... Tipo: Info:eu-repo/semantics/article Palavras-chave: Acetylsalicylic acid; Colon; Giemsa; Mice; Myenteric neurons; Trypanosoma cruzi. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000300804 Neuronal changes caused by Trypanosoma cruzi: an experimental model Anais da ABC (AABC) Moreira,Neide M; Sant'ana,Débora M. G; Araújo,Eduardo J. A; Toledo,Max J. O; Gomes,Mônica L; Araújo,Silvana M. de. Define an experimental model by evaluating quantitative and morphometric changes in myenteric neurons of the colon of mice infected with Trypanosoma cruzi. Twenty-eight Swiss male mice were distributed into groups: control (CG, n=9) and inoculated with 100 (IG100, n=9) and 1000 (IG1000, n=10) blood trypomastigotes, Y strain-T. cruzi II. Parasitemia was evaluated from 3-25 days post inoculation (dpi) with parasites peak of 7.7 × 10(6) and 8.4 × 10(6) trypomastigotes/mL at 8th dpi (p&gt;0.05) in IG100 and IG1000, respectively. Chronic phase of the infection was obtained with two doses of 100mg/Kg/weight and one dose of 250mg/Kg/weight of Benznidazole on 11, 16 and 18 dpi. Three animals from each group were euthanized at 18, 30 and 75 dpi. The colon was... Tipo: Info:eu-repo/semantics/article Palavras-chave: Chagas disease; Colon; Enteric nervous system; Giemsa; Trypanosoma cruzi. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652011000200014 Chagas disease in prehistory Anais da ABC (AABC) Ferreira,Luiz F.; Jansen,Ana M.; Araújo,Adauto. The classical hypothesis proposes that Chagas disease has been originated in the Andean region among prehistoric people when they started domesticating animals, changing to sedentary habits, and adopting agriculture. These changes in their way of life happened nearly 6,000 years ago. However, paleoparasitological data based on molecular tools showed that Trypanosoma cruzi infection and Chagas disease were commonly found both in South and North American prehistoric populations long before that time, suggesting that Chagas disease may be as old as the human presence in the American continent. The study of the origin and dispersion of Trypanosoma cruzi infection among prehistoric human populations may help in the comprehension of the clinical and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Ancient DNA; Chagas disease; Mummies; Paleoepideiology; Paleoparasitology; Trypanosoma cruzi. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652011000300022 The pentose phosphate pathway in Trypanosoma cruzi: a potential target for the chemotherapy of Chagas disease Anais da ABC (AABC) Igoillo-Esteve,Mariana; Maugeri,Dante; Stern,Ana L.; Beluardi,Paula; Cazzulo,Juan J.. Trypanosoma cruzi is highly sensitive to oxidative stress caused by reactive oxygen species. Trypanothione, the parasite's major protection against oxidative stress, is kept reduced by trypanothione reductase, using NADPH; the major source of the reduced coenzyme seems to be the pentose phosphate pathway. Its seven enzymes are present in the four major stages in the parasite's biological cycle; we have cloned and expressed them in Escherichia coli as active proteins. Glucose 6-phosphate dehydrogenase, which controls glucose flux through the pathway by its response to the NADP/NADPH ratio, is encoded by a number of genes per haploid genome, and is induced up to 46-fold by hydrogen peroxide in metacyclic trypomastigotes. The genes encoding... Tipo: Info:eu-repo/semantics/article Palavras-chave: Trypanosoma cruzi; Chagas disease; Pentose phosphate pathway; Oxidative stress; NADPH generation. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652007000400007 Registros recuperados: 95 Primeira ... 1 2 3 4 5 ... Última

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