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| LAMUELA-RAVENTÓS,ROSA M; GIMENO,EVA; FITÓ,MONTSE; CASTELLOTE,ANA-ISABEL; COVAS,MARIBEL; DE LA TORRE-BORONAT,M. CARMEN; LÓPEZ-SABATER,M. CARMEN. |
| Phenolic compounds have shown to inhibit LDL oxidation in vitro and ex vivo; however, they are hydrosoluble compounds while LDL is a lipoprotein. Analysis of phenolic compounds in LDLs by HPLC is necessary to demonstrate their binding capacity to lipoproteins. We developed and validated a solid phase extraction method (SPE) that allowed us the purification of LDL samples and their analysis by HPLC. This methodology allowed us to demonstrate the in vitro binding capacity of tyrosol, one of the main phenolic compounds in olive oil, to LDL. In the intervention dietary study with volunteers, food rich in phenolic compounds affected LDL composition. Changes in LDL phenolics composition are not observed after the short-term ingestion of food rich in phenolic... |
| Tipo: Journal article |
Palavras-chave: Antioxidant; LDL; Olive oil; Oxidation; Phenol; Tyrosol. |
| Ano: 2004 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000200011 |
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| Brilhante,Raimunda Sâmia Nogueira; Caetano,Érica Pacheco; Lima,Rita Amanda Chaves de; Marques,Francisca Jakelyne de Farias; Castelo-Branco,Débora de Souza Collares Maia; Melo,Charlline Vládia Silva de; Guedes,Glaucia Morgana de Melo; Oliveira,Jonathas Sales de; Camargo,Zoilo Pires de; Moreira,José Luciano Bezerra; Monteiro,André Jalles; Bandeira,Tereza de Jesus Pinheiro Gomes; Cordeiro,Rossana de Aguiar; Rocha,Marcos Fábio Gadelha; Sidrim,José Júlio Costa. |
| Abstract This study aimed to evaluate the in vitro antifungal activity of terpinen-4-ol, tyrosol, and β-lapachone against strains of Coccidioides posadasii in filamentous phase (n = 22) and Histoplasma capsulatum in both filamentous (n = 40) and yeast phases (n = 13), using the broth dilution methods as described by the Clinical and Laboratory Standards Institute, to determine the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of these compounds. The mechanisms of action of these compounds were also investigated by analyzing their effect on cell membrane permeability and ergosterol synthesis. The MIC and MFCf these compounds against C. posadasii, mycelial H. capsulatum, and yeast-like H. capsulatum, were in the following... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Dimorphic fungi; Terpinen-4-ol; Tyrosol; Β-Lapachone; Inhibitory effect. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822016000400917 |
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| Specian,Vânia; Sarragiotto,Maria Helena; Pamphile,João Alencar; Clemente,Edmar. |
| Endophytic microorganisms, defined as fungi or bacteria that colonize the interior of plants without causing any immediate negative effects or damages, have reciprocal relationships with host plants. In some cases their presence is beneficial to the host due to the synthesis of bioactive compounds, among which several alcohols, esters, ketones and others that may react with other compounds and may be lethal to pathogenic microorganisms. Diaporthe helianthi (Phomopsis helianthi in its anamorphic phase) is available worldwide, especially in Europe, Asia and America. Isolated in Europe as an agent of the sunflower stem cancer, it has also been endophytically isolated from tropical and temperate plants. A D. helianthi strain isolated from Luehea divaricata has... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Endophytic fungi; Diaporthe helianthi; Secondary metabolite; Phenolic compound; Tyrosol. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822012000300045 |
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