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| Yu,Cheng Hao; Zhao,Jin Shuang; Zhao,Hui; Peng,Teng; Shen,Dong Cheng; Xu,Qiu Xia; Li,Yao; Webb,R. Clinton; Wang,Mong Heng; Shi,Xing Ming; Peng,Cheng; Ding,Wei Jun. |
| The aim of this study was to elucidate the concise effects of a traditional herb pair, Curcumae rhizoma-Sparganii rhizoma (CRSR), on uterine leiomyoma (UL) by analyzing transcriptional profiling. The UL rat model was made by intramuscular injection of progesterone and gavage administration of diethylstilbestrol. From 11 weeks of the establishment of the model, rats of the UL+CRSR group were gavaged daily with CRSR (6.67 g/kg). The serum concentrations of progesterone (P) and estradiol (E2) were determined by radioimmunoassay, the uterine index was measured by caliper measurement, and the pathological status was observed by hematoxylin and eosin stain. Gene expression profiling was checked by NimbleGen Rat Gene Expression Microarrays. The results indicated... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Uterine leiomyoma; Transcriptional profiling; Extracellular matrix; Curcumae rhizoma; Sparganii rhizoma. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000600606 |
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| Yaghmaei,Minoo; Salimi,Saeedeh; Namazi,Lida; Farajian-Mashhadi,Farzaneh. |
| Abstract The aim of present study was to investigate the role of the X-ray repair cross-complementing protein1 (XRCC1) and Tumor protein p53 (Tp53) polymorphisms in Uterine Leiomyoma (UL) susceptibility in southeastern Iran. This case control study was performed on 139 women with UL and 149 age, BMI and ethnicity matched healthy women. All women were genotyped for the XRCC1 Arg399Gln, XRCC1 Arg194Trp and Tp53 Arg72Pro polymorphisms. The frequency of Tp53 72 Pro/Pro genotype was significantly higher in UL women compared to controls. The risk of UL was 1.5 fold higher in women with the Pro/Pro genotype (OR, 1.5 [95% CI, 1.1 to 2.1], p = 0.012). Moreover, the frequency of the Pro allele was significantly higher in the UL women. Although the frequency of XRCC1... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Uterine leiomyoma; Tp53; XRCC1; Polymorphism. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572015000400444 |
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