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| Pejić,Sneana; Todorović,Ana; Stojiljković,Vesna; Cvetković,Dragana; Lučić,Nenad; Radojičić,Ratko M.; Saičić,Zorica S.; Pajovic,Sneana B.. |
| Epidemiological and experimental data point to involvement of oxygen derived radicals in the pathogenesis of gynecological disorders, as well as in cancer development. The objective of the present study was to examine changes in activities and levels of copper/zinc superoxide dismutase (CuZnSOD) and lipid hydroperoxides (LOOH) in blood and endometrial tissue of patients diagnosed with uterine myoma, endometrial polypus, hyperplasia simplex, hyperplasia complex and adenocarcinoma endometrii. The results of our study have shown decreased SOD activities and unchanged SOD protein level in blood of all examined patients in comparison to healthy subjects. Decrease of both SOD activity and level was found in endometrium of patients with hyperplasia simplex,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Copper/zinc superoxide dismutase; Lipid hydroperoxides; Uterine myoma; Endometrial polypus; Endometrial hyperplasia; Endometrial adenocarcinoma. |
| Ano: 2008 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652008000300011 |
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| PEJIC,SNEZANA; KASAPOVIC,JELENA; TODOROVIC,ANA; STOJILJKOVIC,VESNA; PAJOVIC,SNEZANA B. |
| Oxidative stress is considered to be involved in pathogenesis of many disorders of the female genital tract. In this study, we explored the lipid peroxidation levels and antioxidant enzyme activities in women diagnosed with different forms of uterine diseases in order to evaluate the extent of oxidative stress in blood of such patients. Blood samples of healthy subjects and gynecological patients were collected and subjected to assays for superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and lipid hydroperoxides. The results show that alterations of measured parameters vary with the enzyme type and diagnosis. However, both reduction in antioxidants and elevation of lipid peroxidation were observed in general. Lipid... |
| Tipo: Journal article |
Palavras-chave: Antioxidant enzymes; Endometrial polypus; Endometrial hyperplasia; Endometrial adenocarcinoma; Lipid peroxidation; Uterine myoma. |
| Ano: 2006 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000500005 |
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