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	Provedor de dados BJMBR (2) Autor Da,M.X. (1) Duan,Y.X. (1) Qiao,M. (1) Qin,L. (1) Wang,X.L. (1) Yao,J.B. (1) Zhang,Y.B. (1) Zhao,J. (1) Mais... Palavra-chave VEGF-C (2) Acute colitis (1) Gastric cancer (1) Inflammation (1) Lymphangiogenesis (1) Methylation (1) Microvessel density (1) S-adenosylmethionine (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2016 (1) 2014 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Promoting inflammatory lymphangiogenesis by vascular endothelial growth factor-C (VEGF-C) aggravated intestinal inflammation in mice with experimental acute colitis BJMBR Wang,X.L.; Zhao,J.; Qin,L.; Qiao,M.. Angiogenesis and lymphangiogenesis are thought to play a role in the pathogenesis of inflammatory bowel diseases (IBD). However, it is not understood if inflammatory lymphangiogenesis is a pathological consequence or a productive attempt to resolve the inflammation. This study investigated the effect of lymphangiogenesis on intestinal inflammation by overexpressing a lymphangiogenesis factor, vascular endothelial growth factor-C (VEGF-C), in a mouse model of acute colitis. Forty eight-week-old female C57BL/6 mice were treated with recombinant adenovirus overexpressing VEGF-C or with recombinant VEGF-C156S protein. Acute colitis was then established by exposing the mice to 5% dextran sodium sulfate (DSS) for 7 days. Mice were evaluated for disease activity... Tipo: Info:eu-repo/semantics/article Palavras-chave: Inflammation; Lymphangiogenesis; Microvessel density; Acute colitis; VEGF-C. Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000500602 DNA methylation regulates expression of VEGF-C, and S-adenosylmethionine is effective for VEGF-C methylation and for inhibiting cancer growth BJMBR Da,M.X.; Zhang,Y.B.; Yao,J.B.; Duan,Y.X.. DNA hypomethylation may activate oncogene transcription, thus promoting carcinogenesis and tumor development. S-adenosylmethionine (SAM) is a methyl donor in numerous methylation reactions and acts as an inhibitor of intracellular demethylase activity, which results in hypermethylation of DNA. The main objectives of this study were to determine whether DNA hypomethylation correlated with vascular endothelial growth factor-C (VEGF-C) expression, and the effect of SAM on VEGF-C methylation and gastric cancer growth inhibition. VEGF-C expression was assayed by Western blotting and RT-qPCR in gastric cancer cells, and by immunohistochemistry in tumor xenografts. VEGF-C methylation was assayed by bisulfite DNA sequencing. The effect of SAM on cell apoptosis was... Tipo: Info:eu-repo/semantics/article Palavras-chave: VEGF-C; Methylation; S-adenosylmethionine; Gastric cancer. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014001201021 Registros recuperados: 2 Primeira ... 1 ... Última

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